Evidence map›Paper›PMID 34204917›Full record

ArticleCancers2021

Evaluation of Somatic Mutations in Solid Metastatic Pan-Cancer Patients.

Moom R Roosan, Isa Mambetsariev, Rebecca Pharaon, Jeremy Fricke, Angel R Baroz, Joseph Chao, Chen Chen, Mohd W Nasser, Ramakanth Chirravuri-Venkata, Maneesh Jain and 17 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
1.0field-weighted citation impact, top 30% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
  4. Review
  5. Review
  6. Article
  7. Genetic alterations ofOpen life sciences · 2023
    Article
  8. Article
  9. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

27 authors at 4 institutions in 1 country.

Moom R RoosanSchool of Pharmacy, Chapman University, Irvine, CA 92618, USA.
Isa MambetsarievDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Rebecca PharaonDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Jeremy FrickeDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Angel R BarozDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Joseph ChaoDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Chen ChenApplied AI and Data Science, City of Hope, Duarte, CA 91010, USA.
Mohd W NasserDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0003-2070-4972
Ramakanth Chirravuri-VenkataDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Maneesh JainDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Lynette SmithDepartment of Biostatistics, University of Nebraska Medical Center, Omaha, NE 68198, USA.
Susan E YostDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Karen L ReckampDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Raju PillaiDepartment of Pathology, City of Hope, Duarte, CA 91010, USA.
Leonidas ArvanitisDepartment of Pathology, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-4744-8350
Michelle AfkhamiDepartment of Pathology, City of Hope, Duarte, CA 91010, USA.
Edward W WangDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Vincent ChungDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0001-9475-808X
Mihaela CristeaDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Marwan FakihDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Marianna KoczywasDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Erminia MassarelliDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0001-7798-7286
Joanne MortimerDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0002-2935-1934
Yuan YuanDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Surinder K BatraDepartment of Biochemistry and Molecular Biology, University of Nebraska Medical Center, Omaha, NE 68198, USA.ORCID 0000-0001-9470-9317
Sumanta PalDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.
Ravi SalgiaDepartment of Medical Oncology & Therapeutics Research, City of Hope, Duarte, CA 91010, USA.ORCID 0000-0001-9643-7626
City of Hope · USUniversity of Nebraska Medical Center · USCedars-Sinai Medical Center · USChapman University · US

Funding

Transgenic Mouse FacilityP30CA033572 · NCI · CITY OF HOPE/BECKMAN RESEARCH INSTITUTE · PI STANLEY R. HAMILTON · 1985 to 2026
$86.3M
Project 2: Targeting Cooperative Phenotypes Common in Spatial HeterogeneityU54CA209978 · NCI · UNIVERSITY OF UTAH · PI BILD, ANDREA HOPE · 2017 to 2021
$10.5M
Modulation of Tumor Microenvironment for Improved Therapy of Pancreatic CancerR01CA247471 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI BATRA, SURINDER K., JAIN, MANEESH · 2020 to 2024
$2.8M
Novel approach to attenuate small cell lung cancer growth and metastasisR01CA218545 · NCI · UNIVERSITY OF NEBRASKA MEDICAL CENTER · PI NASSER, MOHD WASIM · 2018 to 2022
$2.6M
NCI NIH HHS P30 CA033572NCI NIH HHS P30CA033572NCI NIH HHS R01CA218545NCI NIH HHS R01CA247471NCI NIH HHS U54CA209978
6 · The paper itself

Abstract

Metastasis continues to be the primary cause of all cancer-related deaths despite the recent advancements in cancer treatments. To evaluate the role of mutations in overall survival (OS) and treatment outcomes, we analyzed 957 metastatic patients with seven major cancer types who had available molecular testing results with a FoundationOne CDx

Indexed as

metastatic solid tumorsmolecular testingoverall survivalprogression-free survivalsomatic mutationstargeted therapies

Identifiers

PMID34204917
PMCPMC8199748
OpenAlexW3167786120

What OpenQuestion holds

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LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.