Evidence map›Paper›PMID 34204900›Full record

ArticleAnimals : an open access journal from MDPI2021

The Pen Is Milder Than the Blade: Identification Marking Mice Using Ink on the Tail Appears More Humane Than Ear-Punching Even with Local Anaesthetic.

Charlotte C Burn, Nur H B Mazlan, Natalie Chancellor, Dominic J Wells

Open access · goldAbstract read
In one paragraph

Article in Animals : an open access journal from MDPI, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.1field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Tail-rattling in rodents: more than a threat display.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2026
    Review
  3. Article
  4. The influence of trait anxiety on performance in the CatWalk test.Frontiers in behavioral neuroscience · 2026
    Article
  5. Antidiabetic Effects and Mechanisms of Action of Uncaria gambir Roxb. in Diabetic Sprague-Dawley Rats.Journal of the American Association for Laboratory Animal Science : JAALAS · 2025
    Article
  6. Review
  7. The 3Rs in Experimental Liver Disease.Animals : an open access journal from MDPI · 2023
    Review
  8. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Charlotte C BurnAnimal Welfare Science and Ethics, Royal Veterinary College, Hertfordshire AL9 7TA, UK.ORCID 0000-0002-8734-8610
Nur H B MazlanComparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, UK.
Natalie ChancellorAnimal Welfare Science and Ethics, Royal Veterinary College, Hertfordshire AL9 7TA, UK.
Dominic J WellsComparative Biomedical Sciences, Royal Veterinary College, London NW1 0TU, UK.
Royal Veterinary College · GB

Funding

Ministry of Higher Education, Malaysia and Universiti Putra Malaysia Studentship (N Mazlan)
6 · The paper itself

Abstract

Identification marking mice commonly involves ear-punching with or without anaesthetic, or tail-marking with ink. To identify which is most humane, we marked weanling male BALB/c mice using ear-punching (EP), ear-punching with anaesthetic EMLA

Indexed as

3Rsanimal welfareanxietyculture of careidentification markinglaboratory animalsmicepainrefinementreproducibility

Identifiers

PMID34204900
PMCPMC8227781
OpenAlexW3165963476

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.