MAPKs Are Highly Abundant but Do Not Contribute to α

Dina K Gaynullina, Tatiana V Kudryashova, Alexander V Vorotnikov, Rudolf Schubert, Olga S Tarasova

Open access · goldAbstract read

In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

0.5field-weighted citation impact, top 38% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

Thyroxine Induces Acute Relaxation of Rat Skeletal Muscle Arteries via Integrin αvβ3, ERK1/2 and Integrin-Linked Kinase.Frontiers in physiology · 2021
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 4 institutions in 3 countries.

Dina K GaynullinaDepartment of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia.

Tatiana V KudryashovaDepartment of Internal Medicine, Division of Pulmonary, Critical Care and Sleep Medicine, University of California Davis, Davis, CA 95616, USA.ORCID 0000-0002-2843-5554

Alexander V VorotnikovNational Medical Research Center of Cardiology, Institute of Experimental Cardiology, 121552 Moscow, Russia.

Rudolf SchubertPhysiology, Institute of Theoretical Medicine, Medical Faculty, University of Augsburg, 86159 Augsburg, Germany.ORCID 0000-0003-1777-1461

Olga S TarasovaDepartment of Human and Animal Physiology, Faculty of Biology, M.V. Lomonosov Moscow State University, 119234 Moscow, Russia.

Lomonosov Moscow State University · RUInstitute of Experimental Cardiology · RUUniversity of Augsburg · DEUniversity of California, Davis · US

Funding

Scientific Project of the State Order of the Government of Russian Federation to Lomonosov Moscow State University 121032300071-8

6 · The paper itself

Abstract

Previously, the abundance of p42/44 and p38 MAPK proteins had been shown to be higher in arteries of 1- to 2-week-old compared to 2- to 3-month-old rats. However, the role of MAPKs in vascular tone regulation in early ontogenesis remains largely unexplored. We tested the hypothesis that the contribution of p42/44 and p38 MAPKs to the contraction of peripheral arteries is higher in the early postnatal period compared to adulthood. Saphenous arteries of 1- to 2-week-old and 2- to 3-month-old rats were studied using wire myography and western blotting. The α

Indexed as

AnimalsArteriesEmbryo, MammalianEmbryonic DevelopmentHumansMethoxamineMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Muscle ContractionMuscle, Smoothp38 Mitogen-Activated Protein KinasesPhosphorylationRatsReceptors, Adrenergic, alpha-1MethoxamineMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3p38 Mitogen-Activated Protein KinasesReceptors, Adrenergic, alpha-1early postnatal ontogenesisERK1/functional remodelingp38 MAPKp42/44 MAPKsmooth muscle

Identifiers

PMID34204888

DOI10.3390/ijms22116037

PMCPMC8199737

OpenAlexW3166173704

What OpenQuestion holds

Textmetadata

LicenceCC BY

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.