Evidence map›Paper›PMID 34204843›Full record

ArticleCancers2021

Constitutive PSGL-1 Correlates with CD30 and TCR Pathways and Represents a Potential Target for Immunotherapy in Anaplastic Large T-Cell Lymphoma.

Beatrice Belmonte, Valeria Cancila, Alessandro Gulino, Mohsen Navari, Walter Arancio, Paolo Macor, Andrea Balduit, Sara Capolla, Gaia Morello, Davide Vacca and 9 more

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.6field-weighted citation impact, top 34% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 7 citations in OpenAlex.

  1. Article
  2. Dynamic changes in serum IL-6, TNF-Frontiers in medicine · 2026
    Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

19 authors at 8 institutions in 3 countries.

Beatrice BelmonteTumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.ORCID 0000-0001-9668-0925
Valeria CancilaTumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.
Alessandro GulinoTumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.ORCID 0000-0002-2579-4519
Mohsen NavariDepartment of Medical Biotechnology, School of Paramedical Sciences, Torbat Heydariyeh University of Medical Sciences, Torbat Heydariyeh 95196 33787, Iran.
Walter ArancioAdvanced Data Analysis Group, Fondazione Ri.MED, 90133 Palermo, Italy.ORCID 0000-0002-6736-7734
Paolo MacorDepartment of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Andrea BalduitDepartment of Life Sciences, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0001-5902-3205
Sara CapollaDepartment of Life Sciences, University of Trieste, 34127 Trieste, Italy.
Gaia MorelloTumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.ORCID 0000-0003-3400-8732
Davide VaccaTumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.ORCID 0000-0003-3274-1746
Ines FerraraTumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.
Giorgio BertolazziTumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.
Carmela Rita BalistreriDepartment of BioMedicine, Neuroscience, and Advanced Diagnostics (Bi.N.D.), University of Palermo, 90134 Palermo, Italy.ORCID 0000-0002-5393-1007
Paolo AmicoDepartment of Pathology, Cannizzaro Hospital, 95126 Catania, Italy.
Federica FerranteTumor Immunology Unit, Department of Health Sciences, University of Palermo, 90134 Palermo, Italy.
Antonino MaioranaDepartment of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia, 41121 Modena, Italy.
Tiziana SalviatoDepartment of Medical and Surgical Sciences for Children and Adults, University Hospital of Modena and Reggio Emilia, 41121 Modena, Italy.
Pier Paolo PiccalugaDepartment of Experimental, Diagnostic, and Specialty Medicine, University of Bologna, 40126 Bologna, Italy.ORCID 0000-0002-9432-0595
Alessandro MangognaInstitute for Maternal and Child Health, IRCCS (Istituto di Ricovero e Cura a Carattere Scientifico) "Burlo Garofolo", 34137 Trieste, Italy.ORCID 0000-0001-7910-1274
University of Palermo · ITUniversity of Trieste · ITUniversity of Modena and Reggio Emilia · ITIRCCS Materno Infantile Burlo Garofolo · ITJomo Kenyatta University of Agriculture and Technology · KEMashhad University of Medical Sciences · IROspedale Cannizzaro · ITRi.MED · IT

Funding

Associazione Italiana per la Ricerca sul Cancro IG18 22145
6 · The paper itself

Abstract

Due to the high expression of P-selectin glycoprotein ligand-1 (PSGL-1) in lymphoproliferative disorders and in multiple myeloma, it has been considered as a potential target for humoral immunotherapy, as well as an immune checkpoint inhibitor in T-cells. By investigating the expression of

Indexed as

ALCLALKCD30immunotherapyPSGL-1PTCLTCR

Identifiers

PMID34204843
PMCPMC8231564
OpenAlexW3166921646

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.