Evidence map›Paper›PMID 34204757›Full record

ArticleCells2021

With-No-Lysine Kinase 1 (WNK1) Augments TRPV4 Function in the Aldosterone-Sensitive Distal Nephron.

Viktor N Tomilin, Kyrylo Pyrshev, Naghmeh Hassanzadeh Khayyat, Oleg Zaika, Oleh Pochynyuk

Open access · goldAbstract read
In one paragraph

Article in Cells, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
1.5field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 13 citations in OpenAlex.

  1. Activation of WNK1 signaling through Piezo1.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
  2. Article
  3. Article
  4. WNK kinase is a vasoactive chloride sensor in endothelial cells.Proceedings of the National Academy of Sciences of the United States of America · 2024
    Article
  5. TRPV4 expression in the renal tubule is necessary for maintaining whole body KAmerican journal of physiology. Renal physiology · 2023
    Article
  6. Article
  7. Article
  8. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Viktor N TomilinDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.
Kyrylo PyrshevDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.ORCID 0000-0001-5722-0707
Naghmeh Hassanzadeh KhayyatDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.
Oleg ZaikaDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.
Oleh PochynyukDepartment of Integrative Biology and Pharmacology, The University of Texas Health Science Center at Houston, 6431 Fannin, Houston, TX 77030, USA.
The University of Texas Health Science Center at Houston · US

Funding

Physiology of ClC-K2/b Cl- channel in the collecting ductR01DK117865 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2019 to 2023
$1.7M
Regulation of K+ balance by distal nephron TRPV4 channelR01DK119170 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2018 to 2022
$1.7M
Aldosterone-independent regulation of ENaC by systemic saltR01DK095029 · NIDDK · UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON · PI POCHYNYUK, OLEH · 2012 to 2016
$1.6M
American Heart Association EIA35260097American Heart Association-American Stroke Association AHA-19CDA34660148NIDDK NIH HHS R01 DK095029NIDDK NIH HHS R01 DK117865NIDDK NIH HHS R01 DK119170
6 · The paper itself

Abstract

Kidneys play a central role in regulation of potassium homeostasis and maintenance of plasma K

Indexed as

AldosteroneAnimalsCHO CellsCricetinaeCricetulusKidney Tubules, DistalMicePotassiumTRPV Cation ChannelsWNK Lysine-Deficient Protein Kinase 1AldosteronePotassiumTrpv4 protein, mouseTRPV Cation ChannelsWnk1 protein, mouseWNK Lysine-Deficient Protein Kinase 1ion transportK+ secretionmechanosensitivityrenal tubule

Identifiers

PMID34204757
PMCPMC8231605
OpenAlexW3169614072

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.