Evidence map›Paper›PMID 34204722›Full record

ArticleJournal of personalized medicine2021

Prevalence and Clinicopathological Characteristics of Moderate and High-Penetrance Genes in Non-BRCA1/2 Breast Cancer High-Risk Spanish Families.

Maria Fonfria, Inmaculada de Juan Jiménez, Isabel Tena, Isabel Chirivella, Paula Richart-Aznar, Angel Segura, Ana Beatriz Sánchez-Heras, Eduardo Martinez-Dueñas

Abstract read
In one paragraph

Article in Journal of personalized medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Maria FonfriaCancer Genetic Counseling Unit, Medical Oncology Department, Castellon Provincial Hospital, 12002 Castellon, Spain.
Inmaculada de Juan JiménezMolecular Biology Unit, Service of Clinical Analysis, La Fe University Hospital, 46026 Valencia, Spain.
Isabel TenaCancer Genetic Counseling Unit, Medical Oncology Department, Castellon Provincial Hospital, 12002 Castellon, Spain.
Isabel ChirivellaMedical Oncology Department, INCLIVA Biomedical Research Institute, University of Valencia, 46001 Valencia, Spain.ORCID 0000-0002-0733-3276
Paula Richart-AznarCancer Genetic Counseling Unit, Medical Oncology Department, La Fe University Hospital, 46026 Valencia, Spain.
Angel SeguraCancer Genetic Counseling Unit, Medical Oncology Department, La Fe University Hospital, 46026 Valencia, Spain.ORCID 0000-0002-5245-2610
Ana Beatriz Sánchez-HerasCancer Genetic Counseling Unit, Medical Oncology Department, Elche University Hospital, 03203 Elche, Spain.
Eduardo Martinez-DueñasCancer Genetic Counseling Unit, Medical Oncology Department, Castellon Provincial Hospital, 12002 Castellon, Spain.

Funding

Fundación Le Cadó PRV00039
6 · The paper itself

Abstract

(1) Background: Over the last decade, genetic counseling clinics have moved from single-gene sequencing to multigene panel sequencing. Multiple genes related to a moderate risk of breast cancer (BC) have emerged, although many questions remain regarding the risks and clinical features associated with these genes. (2) Methods: Ninety-six BC index cases (ICs) with high-risk features for hereditary breast and ovarian cancer (HBOC) and with a previous uninformative result for

Indexed as

BRCA1 or BRCA2 negativegermline testinghereditary breast and ovarian cancermoderate penetrance genesnext-generation sequencing

Identifiers

PMID34204722
PMCPMC8231620

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.