Evidence map›Paper›PMID 34204653›Full record

ReviewInternational journal of molecular sciences2021

Contextualizing Autophagy during Gametogenesis and Preimplantation Embryonic Development.

Marcelo T Moura, Laís B Latorraca, Fabíola F Paula-Lopes

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
  2. Article
  3. Frontiers in veterinary science · 2025
    Article
  4. Review
  5. Signaling pathway regulators in preimplantation embryos.Journal of molecular histology · 2024
    Review
  6. Article
  7. Article
  8. Article
  9. Review
  10. Article
  11. Article
  12. Amino Acids and the Early Mammalian Embryo: Origin, Fate, Function and Life-Long Legacy.International journal of environmental research and public health · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Marcelo T MouraDepartment of Biological Sciences, Campus Diadema, Federal University of Sao Paulo-UNIFESP, Diadema 09972-270, SP, Brazil.ORCID 0000-0003-3808-6607
Laís B LatorracaDepartment of Biological Sciences, Campus Diadema, Federal University of Sao Paulo-UNIFESP, Diadema 09972-270, SP, Brazil.ORCID 0000-0002-0842-6319
Fabíola F Paula-LopesDepartment of Biological Sciences, Campus Diadema, Federal University of Sao Paulo-UNIFESP, Diadema 09972-270, SP, Brazil.ORCID 0000-0001-5009-3450
Universidade Federal de São Paulo · BR

Funding

Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (CAPES) Financial code 101Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) 2017/13082-6Fundação de Amparo à Pesquisa do Estado de São Paulo (FAPESP) grant 2017/20125-3
6 · The paper itself

Abstract

Mammals face environmental stressors throughout their lifespan, which may jeopardize cellular homeostasis. Hence, these organisms have acquired mechanisms to cope with stressors by sensing, repairing the damage, and reallocating resources to increase the odds of long-term survival. Autophagy is a pro-survival lysosome-mediated cytoplasm degradation pathway for organelle and macromolecule recycling. Furthermore, autophagy efflux increases, and this pathway becomes idiosyncratic depending upon developmental and environmental contexts. Mammalian germ cells and preimplantation embryos are attractive models for dissecting autophagy due to their metastable phenotypes during differentiation and exposure to varying environmental cues. The aim of this review is to explore autophagy during mammalian gametogenesis, fertilization and preimplantation embryonic development by contemplating its physiological role during development, under key stressors, and within the scope of assisted reproduction technologies.

Indexed as

AutophagyEmbryonic DevelopmentGametogenesisAnimalsHumansModels, BiologicalOogenesisSpermatogenesisARTautophagiccloningembryogenesisoogenesisreproductionreprogrammingspermatozoa

Identifiers

PMID34204653
PMCPMC8231133
OpenAlexW3167762703

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.