Evidence map›Paper›PMID 34204635›Full record

ArticleNutrients2021

Ferulic Acid Derivatives and Avenanthramides Modulate Endothelial Function through Maintenance of Nitric Oxide Balance in HUVEC Cells.

Gabriele Serreli, Melanie Le Sayec, Estelle Thou, Camille Lacour, Camilla Diotallevi, Misbah Arshad Dhunna, Monica Deiana, Jeremy P E Spencer, Giulia Corona

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
1.5field-weighted citation impact, top 20% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 28 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 3 institutions in 2 countries.

Gabriele SerreliHealth Sciences Research Centre, Life Sciences Department, Whitelands College, University of Roehampton, London SW15 4JD, UK.ORCID 0000-0002-1971-3989
Melanie Le SayecHealth Sciences Research Centre, Life Sciences Department, Whitelands College, University of Roehampton, London SW15 4JD, UK.
Estelle ThouHealth Sciences Research Centre, Life Sciences Department, Whitelands College, University of Roehampton, London SW15 4JD, UK.
Camille LacourHealth Sciences Research Centre, Life Sciences Department, Whitelands College, University of Roehampton, London SW15 4JD, UK.
Camilla DiotalleviHealth Sciences Research Centre, Life Sciences Department, Whitelands College, University of Roehampton, London SW15 4JD, UK.
Misbah Arshad DhunnaHealth Sciences Research Centre, Life Sciences Department, Whitelands College, University of Roehampton, London SW15 4JD, UK.
Monica DeianaDepartment of Biomedical Sciences, University of Cagliari, Cittadella Universitaria, SS 554, km 4.5, 09042 Monserrato, Italy.ORCID 0000-0002-7166-1856
Jeremy P E SpencerMolecular Nutrition Group, Food and Nutritional Sciences Department, University of Reading, Reading RG6 6AP, UK.
Giulia CoronaHealth Sciences Research Centre, Life Sciences Department, Whitelands College, University of Roehampton, London SW15 4JD, UK.ORCID 0000-0002-4323-5198
University of Roehampton · GBUniversity of Cagliari · ITUniversity of Reading · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M002802/1
6 · The paper itself

Abstract

Wholegrain oats contain a variety of phenolic compounds thought to help maintain healthy vascular function, through the maintenance of local levels of the vasodilator nitric oxide (NO). Thus, the full molecular mechanisms involved are not yet clear. With this work we aim to understand the possible cellular mechanisms by which avenanthramides and ferulic acid derivatives, present in oats, may help maintain a healthy vascular function through the modulation of the NO pathway. Primary Human Umbilical Vein Endothelial Cells (HUVEC) were exposed to ferulic acid, isoferulic acid, hydroferulic acid, ferulic acid 4-

Indexed as

Coumaric AcidsEndothelium, VascularHumansHuman Umbilical Vein Endothelial CellsNitric Oxideortho-AminobenzoatesSignal TransductionVasodilator AgentsCoumaric Acidsferulic acidNitric Oxideortho-AminobenzoatesVasodilator Agentsavenanthramidesbioactiveendothelial cellseNOSferulic acidnitric oxidesuperoxidevascular function

Identifiers

PMID34204635
PMCPMC8231282
OpenAlexW3171407970

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.