ArticleJournal of clinical medicine2021
High Myopia and the Complement System: Factor H in Myopic Maculopathy.
Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 24 citations in OpenAlex.
- Relationship between choroidal thickness changes and macrophage polarization in high myopia.Frontiers in medicine · 2026Review
- Prevalence of high myopia and its associated factors among secondary school students at Finote-selam town, Northwest Ethiopia, 2023.Scientific reports · 2025Article
- Visual outcomes of cataract surgery using multifocal intraocular lenses in young adults with developmental vs. nondevelopmental cataracts.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2025Article
- Association Between Inflammatory Cytokines and Refractive Errors: A Bidirectional Mendelian Randomization Study.Translational vision science & technology · 2025Article
- The role of NF-κB pathway and its regulation of inflammatory cytokines in scleral remodeling of form-deprivation mice model.Immunologic research · 2025Article
- Expression of LncRNAs in anterior capsule of lens in patients with pathologic myopia complicated with cataract.International ophthalmology · 2024Article
- Diurnal Variation in Choroidal Parameters Among Healthy Subjects Using Wide-Field Swept-Source Optical Coherence Tomography Angiography.Translational vision science & technology · 2024Article
- Expression of cytokines in the aqueous humor of cataract patients with pathologic myopia and simple high myopia.Molecular vision · 2024Article
- Insights into myopic choroidal neovascularization based on quantitative proteomics analysis of the aqueous humor.BMC genomics · 2023Article
- Whole-Exome Sequencing of 21 Families: Candidate Genes for Early-Onset High Myopia.International journal of molecular sciences · 2023Article
- Widespread Involvement of Acetylation in the Retinal Metabolism of Form-Deprivation Myopia in Guinea Pigs.ACS omega · 2023Article
- Intraocular complement activation is related to retinal vascular and neuronal degeneration in myopic retinopathy.Frontiers in cellular neuroscience · 2023Article
- Long non-coding RNAs in Sus scrofa ileum under starvation stress.Animal bioscience · 2022Article
- Next-Generation Sequencing Screening of 43 Families with Non-Syndromic Early-Onset High Myopia: A Clinical and Genetic Study.International journal of molecular sciences · 2022Article
- Complement and local ocular inflammatory response: Chronic immune factors in myopia.Science progressReview
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
High myopia (HM) is both a medical problem and refractive error of the eye owing to excessive eyeball length, which progressively makes eye tissue atrophic, and is one of the main causes for diminishing visual acuity in developed countries. Despite its high prevalence and many genetic and proteomic studies, no molecular pattern exists that explain the degenerative process underlying HM, which predisposes patients to other diseases like glaucoma, cataracts, retinal detachment and chorioretinal atrophy that affect the macular area. To determine the relation between complement Factors H (CFH) and D (CFD) and the maculopathy of patients with degenerative myopia, we studied aqueous humor samples that were collected by aspiration from 122 patients during cataract surgery. Eyes were classified according to eyeball axial length as high myopia (axial length > 26 mm), low myopia (axial length 23.5-25.9 mm) and control (axial length ˂ 23.4 mm). The degree of maculopathy was classified according to fundus oculi findings following IMI's classification. Subfoveal choroid thickness was measured by optical coherence tomography. CFH and CFD measurements were taken by ELISA. CFH levels were significantly high in the high myopia group vs. the low myopia and control groups (
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