Evidence map›Paper›PMID 34204601›Full record

ArticleMolecules (Basel, Switzerland)2021

In Vitro Effects of Sulforaphane on Interferon-Driven Inflammation and Exploratory Evaluation in Two Healthy Volunteers.

Elena Genova, Maura Apollonio, Giuliana Decorti, Alessandra Tesser, Alberto Tommasini, Gabriele Stocco

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.2field-weighted citation impact, top 52% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Article
  2. Nutraceuticals in Immune Function.Molecules (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 1 country.

Elena GenovaInstitute for Maternal and Child Health IRCCS Burlo Garofolo, 34137 Trieste, Italy.ORCID 0000-0002-6692-6573
Maura ApollonioInstitute for Maternal and Child Health IRCCS Burlo Garofolo, 34137 Trieste, Italy.ORCID 0000-0001-5452-8255
Giuliana DecortiInstitute for Maternal and Child Health IRCCS Burlo Garofolo, 34137 Trieste, Italy.ORCID 0000-0002-9714-6246
Alessandra TesserInstitute for Maternal and Child Health IRCCS Burlo Garofolo, 34137 Trieste, Italy.ORCID 0000-0001-6267-3794
Alberto TommasiniInstitute for Maternal and Child Health IRCCS Burlo Garofolo, 34137 Trieste, Italy.ORCID 0000-0002-6943-7927
Gabriele StoccoDepartment of Life Sciences, University of Trieste, 34127 Trieste, Italy.ORCID 0000-0003-0964-5879
IRCCS Materno Infantile Burlo Garofolo · ITUniversity of Trieste · IT

Funding

IRCCS Burlo Garofolo RC#24/2017 and 07/2014
6 · The paper itself

Abstract

Interferonopathies are rare genetic conditions defined by systemic inflammatory episodes caused by innate immune system activation in the absence of pathogens. Currently, no targeted drugs are authorized for clinical use in these diseases. In this work, we studied the contribution of sulforaphane (SFN), a cruciferous-derived bioactive molecule, in the modulation of interferon-driven inflammation in an immortalized human hepatocytes (IHH) line and in two healthy volunteers, focusing on

Indexed as

AdultCell Line, TumorFemaleGene ExpressionGenotypeGlutathione TransferaseHealthy VolunteersHepatocytesHumansImmunity, InnateInflammationInterferonsIsothiocyanatesMaleMembrane ProteinsSTING ProteinGlutathione TransferaseInterferonsIsothiocyanatesMembrane ProteinsSTING1 protein, humanSTING ProteinsulforaphaneSulfoxidesGSTM1interferon signatureSTINGsulforaphanetype I interferons

Identifiers

PMID34204601
PMCPMC8231268
OpenAlexW3168453531

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.