Evidence map›Paper›PMID 34204586›Full record

ReviewInternational journal of molecular sciences2021

Environmental Factors Affecting Thyroid-Stimulating Hormone and Thyroid Hormone Levels.

Mirjana Babić Leko, Ivana Gunjača, Nikolina Pleić, Tatijana Zemunik

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 103 papers, 5 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
103citing papers in PubMed, 5 pooled it
17.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

103 citing papers in PubMed, 5 syntheses or guidelines pooled it, 244 citations in OpenAlex.

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43 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Mirjana Babić LekoDepartment of Medical Biology, School of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia.ORCID 0000-0003-4223-4190
Ivana GunjačaDepartment of Medical Biology, School of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia.ORCID 0000-0002-7056-6443
Nikolina PleićDepartment of Medical Biology, School of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia.ORCID 0000-0001-5672-871X
Tatijana ZemunikDepartment of Medical Biology, School of Medicine, University of Split, Šoltanska 2, 21000 Split, Croatia.ORCID 0000-0001-8120-2891
University of Split · HR

Funding

Hrvatska Zaklada za Znanost 2593
6 · The paper itself

Abstract

Thyroid hormones are necessary for the normal functioning of physiological systems. Therefore, knowledge of any factor (whether genetic, environmental or intrinsic) that alters the levels of thyroid-stimulating hormone (TSH) and thyroid hormones is crucial. Genetic factors contribute up to 65% of interindividual variations in TSH and thyroid hormone levels, but many environmental factors can also affect thyroid function. This review discusses studies that have analyzed the impact of environmental factors on TSH and thyroid hormone levels in healthy adults. We included lifestyle factors (smoking, alcohol consumption, diet and exercise) and pollutants (chemicals and heavy metals). Many inconsistencies in the results have been observed between studies, making it difficult to draw a general conclusion about how a particular environmental factor influences TSH and thyroid hormone levels. However, lifestyle factors that showed the clearest association with TSH and thyroid hormones were smoking, body mass index (BMI) and iodine (micronutrient taken from the diet). Smoking mainly led to a decrease in TSH levels and an increase in triiodothyronine (T3) and thyroxine (T4) levels, while BMI levels were positively correlated with TSH and free T3 levels. Excess iodine led to an increase in TSH levels and a decrease in thyroid hormone levels. Among the pollutants analyzed, most studies observed a decrease in thyroid hormone levels after exposure to perchlorate. Future studies should continue to analyze the impact of environmental factors on thyroid function as they could contribute to understanding the complex background of gene-environment interactions underlying the pathology of thyroid diseases.

Indexed as

EnvironmentGene-Environment InteractionGene Expression RegulationAnimalsBiomarkersDietEnvironmental PollutantsGenetic BackgroundHumansLife StyleThyroid HormonesThyrotropinBiomarkersEnvironmental PollutantsThyroid HormonesThyrotropinchemicalsdietenvironmental factorslifestyle factorspollutantsthyroid hormonesTSH

Identifiers

PMID34204586
PMCPMC8234807
OpenAlexW3167605627

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.