Evidence map›Paper›PMID 34204506›Full record

ArticleInternational journal of molecular sciences2021

Ergosta-7, 9 (11), 22-trien-3β-ol Interferes with LPS Docking to LBP, CD14, and TLR4/MD-2 Co-Receptors to Attenuate the NF-κB Inflammatory Pathway

Wen-Tsong Hsieh, Min-Hsien Hsu, Wen-Jen Lin, Yi-Cheng Xiao, Ping-Chiang Lyu, Yi-Chung Liu, Wei-Yong Lin, Yueh-Hsiung Kuo, Jing-Gung Chung

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.8field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 16 citations in OpenAlex.

  1. Article
  2. Review
  3. Review
  4. Article
  5. Immunopharmacological Insights intoCurrent pharmaceutical design · 2025
    Review
  6. Article
  7. Article
  8. Review
  9. Review
  10. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 5 institutions in 1 country.

Wen-Tsong HsiehDepartment of Pharmacology, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0002-2330-8898
Min-Hsien HsuDepartment of Neurology, Chang Bing Show-Chwan Memorial Hospital, Changhua 505, Taiwan.
Wen-Jen LinGraduate Institute of Biomedicine Science, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0001-9568-9178
Yi-Cheng XiaoSchool of Medicine, College of Medicine, National Cheng Kung University, Tainan 701, Taiwan.
Ping-Chiang LyuInstitute of Bioinformatics and Structural Biology, National Tsing-Hua University, Hsinchu 300044, Taiwan.ORCID 0000-0002-6824-543X
Yi-Chung LiuInstitute of Population Health Sciences, National Health Research Institutes, Miaoli 350, Taiwan.ORCID 0000-0003-1437-0363
Wei-Yong LinGraduate Institute of Integrated Medicine, College of Chinese Medicine, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0002-8443-6180
Yueh-Hsiung KuoChinese Medicine Research Center, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0001-5935-6755
Jing-Gung ChungDepartment of Biological Science and Technology, China Medical University, Taichung 40402, Taiwan.ORCID 0000-0002-7303-2287
China Medical University · TWChang Bing Show Chwan Memorial Hospital · TWNational Cheng Kung University · TWNational Health Research Institutes · TWNational Tsing Hua University · TW

Funding

China Medical University CMU107-ASIA-24Drug Development Center & Chinese Medicine Research Center, China Medical University from Featured Areas Research Center Program within the Higher Education Sprout Project frame-work by the Ministry of Education (MOE) in Taiwan CMRC-CHM-4
6 · The paper itself

Abstract

Ergosta-7, 9 (11), 22-trien-3β-ol (EK100) was isolated from

Indexed as

AnimalsAnti-Inflammatory AgentsCell SurvivalCyclooxygenase 2CytokinesDrosophilaInflammation MediatorsLipopolysaccharide ReceptorsLipopolysaccharidesLymphocyte Antigen 96MacrophagesMiceModels, MolecularMolecular ConformationNF-kappa BNitric Oxide Synthase Type IIAnti-Inflammatory AgentsCyclooxygenase 2CytokinesInflammation MediatorsLipopolysaccharide ReceptorsLipopolysaccharidesLymphocyte Antigen 96NF-kappa BNitric Oxide Synthase Type IIToll-Like Receptor 4CD14DrosophilaErgosta-7, 9 (11), 22-trien-3β-ol (EK100)LBPLPSNF-κBTLR4/MD-2

Identifiers

PMID34204506
PMCPMC8234490
OpenAlexW3171592422

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.