Evidence map›Paper›PMID 34204453›Full record

ArticleJournal of clinical medicine2021

Direct Comparison of Clinical Characteristics, Outcomes, and Risk Prediction in Patients with COVID-19 and Controls-A Prospective Cohort Study.

Maurin Lampart, Marco Rüegg, Andrea S Jauslin, Noemi R Simon, Núria Zellweger, Ceylan Eken, Sarah Tschudin-Sutter, Stefano Bassetti, Katharina M Rentsch, Martin Siegemund and 5 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 43% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors at 2 institutions in 1 country.

Maurin LampartDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Spitalstrasse 2, 4056 Basel, Switzerland.ORCID 0000-0002-3720-2584
Marco RüeggEmergency Department, University Hospital Basel, Petersgraben 2, 4031 Basel, Switzerland.
Andrea S JauslinEmergency Department, University Hospital Basel, Petersgraben 2, 4031 Basel, Switzerland.
Noemi R SimonEmergency Department, University Hospital Basel, Petersgraben 2, 4031 Basel, Switzerland.
Núria ZellwegerIntensive Care Unit, University Hospital Basel, Petersgraben 2, 4031 Basel, Switzerland.ORCID 0000-0002-3202-2365
Ceylan EkenDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Spitalstrasse 2, 4056 Basel, Switzerland.
Sarah Tschudin-SutterDivision of Infectious Diseases and Hospital Epidemiology, University Hospital Basel, Petersgraben 2, 4031 Basel, Switzerland.
Stefano BassettiDivision of Internal Medicine, University Hospital Basel, Petersgraben 2, 4031 Basel, Switzerland.ORCID 0000-0003-1729-1425
Katharina M RentschLaboratory Medicine, University Hospital Basel, Petersgraben 2, 4031 Basel, Switzerland.
Martin SiegemundIntensive Care Unit, University Hospital Basel, Petersgraben 2, 4031 Basel, Switzerland.ORCID 0000-0002-2013-4140
Roland BingisserEmergency Department, University Hospital Basel, Petersgraben 2, 4031 Basel, Switzerland.
Christian H NickelEmergency Department, University Hospital Basel, Petersgraben 2, 4031 Basel, Switzerland.
Stefan OsswaldDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Spitalstrasse 2, 4056 Basel, Switzerland.ORCID 0000-0002-9240-6731
Gabriela M KusterDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Spitalstrasse 2, 4056 Basel, Switzerland.ORCID 0000-0002-8209-4631
Raphael TwerenboldDepartment of Cardiology and Cardiovascular Research Institute Basel (CRIB), University Hospital Basel, University of Basel, Spitalstrasse 2, 4056 Basel, Switzerland.ORCID 0000-0003-3814-6542
University Hospital of Basel · CHUniversity of Basel · CH

Funding

Cardiovascular Research Foundation Basel NARoche Diagnostics NASchweizerische Herzstiftung NA
6 · The paper itself

Abstract

Most studies investigating early risk predictors in coronavirus disease 19 (COVID-19) lacked comparison with controls. We aimed to assess and directly compare outcomes and risk predictors at time of emergency department (ED) presentation in COVID-19 and controls. Consecutive patients presenting to the ED with suspected COVID-19 were prospectively enrolled. COVID-19-patients were compared with (i) patients tested negative (overall controls) and (ii) patients tested negative, who had a respiratory infection (respiratory controls). Primary outcome was the composite of intensive care unit (ICU) admission and death at 30 days. Among 1081 consecutive cases, 191 (18%) were tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and 890 (82%) were tested negative (overall controls), of which 323 (30%) had a respiratory infection (respiratory controls). Incidence of the composite outcome was significantly higher in COVID-19 (23%) as compared with the overall control group (10%, adjusted-HR 2.45 (95%CI, 1.61-3.74),

Indexed as

characteristicscomparisoncontrolsCOVID-19outcomerisk predictionSARS-CoV-2

Identifiers

PMID34204453
PMCPMC8234319
OpenAlexW3171104261

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.