Evidence map›Paper›PMID 34204360›Full record

ArticleBiomolecules2021

Cold Atmospheric Plasma Promotes the Immunoreactivity of Granulocytes In Vitro.

Laura S Kupke, Stephanie Arndt, Simon Lenzer, Sophia Metz, Petra Unger, Julia L Zimmermann, Anja-Katrin Bosserhoff, Michael Gruber, Sigrid Karrer

Open access · goldAbstract read
In one paragraph

Article in Biomolecules, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed, 1 pooled it
2.7field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 1 synthesis or guideline pooled it, 25 citations in OpenAlex.

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  12. [Mechanism of cold atmospheric plasma in treatment of chronic skin ulcer].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 2 institutions in 1 country.

Laura S KupkeDepartment of Anesthesiology, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-5139-0200
Stephanie ArndtDepartment of Dermatology, University Hospital Regensburg, 93053 Regensburg, Germany.
Simon LenzerDepartment of Anesthesiology, University Hospital Regensburg, 93053 Regensburg, Germany.
Sophia MetzDepartment of Anesthesiology, University Hospital Regensburg, 93053 Regensburg, Germany.
Petra UngerDepartment of Dermatology, University Hospital Regensburg, 93053 Regensburg, Germany.
Julia L ZimmermannTerraplasma Medical GmbH, 85748 Garching, Germany.
Anja-Katrin BosserhoffEmil-Fischer-Center, Institute of Biochemistry, University of Erlangen-Nuernberg (FAU), 91054 Erlangen, Germany.ORCID 0000-0001-8147-394X
Michael GruberDepartment of Anesthesiology, University Hospital Regensburg, 93053 Regensburg, Germany.ORCID 0000-0002-5509-9760
Sigrid KarrerDepartment of Dermatology, University Hospital Regensburg, 93053 Regensburg, Germany.
University Hospital Regensburg · DEFriedrich-Alexander-Universität Erlangen-Nürnberg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Cold atmospheric plasma (CAP) reduces bacteria and interacts with tissues and cells, thus improving wound healing. The CAP-related induction of neutrophils was recently described in stained sections of wound tissue in mice. Consequently, this study aimed to examine the functionality of human polymorphonuclear cells (PMN)/granulocytes through either a plasma-treated solution (PTS) or the direct CAP treatment with different plasma modes and treatment durations. PTS analysis yielded mode-dependent differences in the production of reactive oxygen species (ROS) and reactive nitrogen species (RNS) after CAP treatment. Live-cell imaging did not show any chemo-attractive or NETosis-inducing effect on PMNs treated with PTS. The time to maximum ROS production (T

Indexed as

ApoptosisGene Expression RegulationGranulocytesHumansIntegrinsPlasma GasesReactive Nitrogen SpeciesReactive Oxygen SpeciesSelectinsIntegrinsPlasma GasesReactive Nitrogen SpeciesReactive Oxygen SpeciesSelectinscold atmospheric plasmaflow cytometrygranulocyteslive-cell imagingNETosiswound treatment

Identifiers

PMID34204360
PMCPMC8235417
OpenAlexW3170218657

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.