Evidence map›Paper›PMID 34204339›Full record

ReviewPharmaceuticals (Basel, Switzerland)2021

Zebrafish as a Screening Model to Study the Single and Joint Effects of Antibiotics.

Roxana Jijie, Gabriela Mihalache, Ioana-Miruna Balmus, Stefan-Adrian Strungaru, Emanuel Stefan Baltag, Alin Ciobica, Mircea Nicoara, Caterina Faggio

Abstract readReview
In one paragraph

Review in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
18citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

18 citing papers in PubMed, 1 synthesis or guideline pooled it.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Review
  6. Intestinal Microbial Profiles of Wild Zobaidy (Current issues in molecular biology · 2025
    Article
  7. Review
  8. Article
  9. Review
  10. Article
  11. Article
  12. Article
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. Insulin-Mimic Components inPharmaceuticals (Basel, Switzerland) · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Roxana JijieMarine Biological Station "Prof. dr. I. Borcea", "Alexandru Ioan Cuza" University of Iasi, Nicolae Titulescu Street, No. 163, 9007018 Agigea, Romania.
Gabriela MihalacheIntegrated Center of Environmental Science Studies in the North Eastern Region (CERNESIM), "Alexandru Ioan Cuza" University of Iasi, 11 Carol I, 700506 Iasi, Romania.
Ioana-Miruna BalmusDepartment of Exact and Natural Sciences, Institute of Interdisciplinary Research, "Alexandru Ioan Cuza" University of Iasi, 11 Carol I, 700506 Iasi, Romania.
Stefan-Adrian StrungaruDepartment of Exact and Natural Sciences, Institute of Interdisciplinary Research, "Alexandru Ioan Cuza" University of Iasi, 11 Carol I, 700506 Iasi, Romania.ORCID 0000-0001-7958-4923
Emanuel Stefan BaltagMarine Biological Station "Prof. dr. I. Borcea", "Alexandru Ioan Cuza" University of Iasi, Nicolae Titulescu Street, No. 163, 9007018 Agigea, Romania.ORCID 0000-0002-3107-0349
Alin CiobicaDepartment of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, B-dul Carol I, 700505 Iasi, Romania.
Mircea NicoaraDepartment of Biology, Faculty of Biology, "Alexandru Ioan Cuza" University of Iasi, B-dul Carol I, 700505 Iasi, Romania.ORCID 0000-0002-9755-6771
Caterina FaggioDepartment of Chemical, Biological, Pharmaceutical and Environmental Sciences, University of Messina, Viale F. Stagno, d'Alcontres, 31 98166 S. Agata-Messina, Italy.ORCID 0000-0002-0066-2421

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The overuse of antibiotics combined with the limitation of wastewater facilities has resulted in drug residue accumulation in the natural environment. Thus, in recent years, the presence of antibiotic residues in the environment has raised concerns over the potential harmful effects on ecosystems and human health. The in vivo studies represent an essential step to study the potential impact induced by pharmaceutical exposure. Due to the limitations of traditional vertebrate model systems, zebrafish (

Indexed as

antibioticsaquatic environmentcombined effectstoxicityzebrafish

Identifiers

PMID34204339
PMCPMC8234794

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.