ArticleNutrients2021
Maternal Folic Acid Intake and Methylation Status of Genes Associated with Ventricular Septal Defects in Children: Case-Control Study.
Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
9 citing papers in PubMed, 14 citations in OpenAlex.
- DNA Methylation and Fetal Programming of Cardiovascular Disease: From Congenital Heart Diseases to Adult Cardiovascular Dysfunction.Reviews in cardiovascular medicine · 2026Review
- Association of Maternal Dietary Habits and InfantNutrients · 2024Article
- Initiation and duration of folic acid supplementation in preventing congenital malformations.BMC medicine · 2023Article
- Predictors of ICU Admission in Children with COVID-19: Analysis of a Large Mexican Population Dataset.Journal of clinical medicine · 2023Article
- Epigenetics applied to child and adolescent mental health: Progress, challenges and opportunities.JCPP advances · 2023Article
- Epigenetic Evaluation of theCells · 2023Article
- Asinine milk mitigates stress-mediated immune, cortisol and behavioral responses of piglets to weaning: A study to foster future interventions in humans.Frontiers in immunology · 2023Article
- Article
- Epigenetic Effect of Maternal Methyl-Group Donor Intake on Offspring's Health and Disease.Life (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
10 authors at 2 institutions in 2 countries.
Funding
Abstract
backgroundDNA methylation is the best epigenetic mechanism for explaining the interactions between nutrients and genes involved in intrauterine growth and development programming. A possible contributor of methylation abnormalities to congenital heart disease is the folate methylation regulatory pathway; however, the mechanisms and methylation patterns of VSD-associated genes are not fully understood.
objectiveTo determine if maternal dietary intake of folic acid (FA) is related to the methylation status (MS) of VSD-associated genes (AXIN1, MTHFR, TBX1, and TBX20).
methodsProspective case-control study; 48 mothers and their children were evaluated. The mothers' dietary variables were collected through a food frequency questionnaire focusing on FA and the consumption of supplements with FA. The MS of promoters of genes was determined in the children.
resultsThe intake of FA supplements was significantly higher in the control mothers. In terms of maternal folic acid consumption, significant differences were found in the first trimester of pregnancy. Significant differences were observed in the MS of MTHFR and AXIN1 genes in VSD and control children. A correlation between maternal FA supplementation and MS of AXIN1 and TBX20 genes was found in control and VSD children, respectively.
conclusionsA lower MS of AXIN1 genes and a higher MS of TBX20 genes is associated with FA maternal supplementation.
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Registered trials
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