Evidence map›Paper›PMID 34204320›Full record

ArticleInternational journal of neonatal screening2021

Successful Implementation of Newborn Screening for Hemoglobin Disorders in the Philippines.

Carmencita D Padilla, Bradford L Therrell, Maria Melanie Liberty B Alcausin, Reynaldo C de Castro, Maria Beatriz P Gepte, Ma Elouisa L Reyes, Charity M Jomento, Riza Concordia N Suarez, Ebner Bon G Maceda, Conchita G Abarquez and 6 more

Open access · goldAbstract read
In one paragraph

Article in International journal of neonatal screening, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
1.2field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 14 citations in OpenAlex.

  1. Review
  2. Thalassaemia.Nature reviews. Disease primers · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

16 authors at 5 institutions in 2 countries.

Carmencita D PadillaNewborn Screening Reference Center, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Bradford L TherrellNational Newborn Screening and Global Resource Center, Austin, TX 78759, USA.
Maria Melanie Liberty B AlcausinNewborn Screening Reference Center, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Reynaldo C de CastroNewborn Screening Reference Center, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Maria Beatriz P GepteNewborn Screening Reference Center, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Ma Elouisa L ReyesNewborn Screening Reference Center, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Charity M JomentoNewborn Screening Reference Center, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Riza Concordia N SuarezNewborn Screening Reference Center, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.
Ebner Bon G MacedaNewborn Screening Reference Center, National Institutes of Health, University of the Philippines Manila, Manila 1000, Philippines.ORCID 0000-0001-5414-7030
Conchita G AbarquezNewborn Screening Center-Mindanao, Southern Philippine Medical Center, Davao 8000, Philippines.
J Edgar Winston C PosecionNewborn Screening Center-Visayas, West Visayas State University Medical Center, Iloilo City 5000, Philippines.
Alma P AndalNewborn Screening Center-Southern Luzon, Daniel O. Mercado Medical Center, Tanauan City 4232, Philippines.
Anna Lea G ElizagaNewborn Screening Center-National Institutes of Health, Quezon City 1101, Philippines.
Bernadette C Halili-MendozaNewborn Screening Center-Central Luzon, Angeles City University Foundation Medical Center, Angeles City 2009, Philippines.
Maria Paz Virginia K OtayzaNewborn Center-Northern Luzon, Mariano Marcos Memorial Hospital and Medical Center, Batac City 2906, Philippines.
Carolyn C HoppeUCSF Benioff Children's Hospital Oakland, Oakland, CA 94609, USA.
University of the Philippines Manila · PHAngeles University Foundation · PHGlobal Blood Therapeutics (United States) · USThe University of Texas Health Science Center at San Antonio · USWest Visayas State University · PH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The Philippine newborn bloodspot screening (NBS) program began in 1996 with 24 hospitals and was formalized by legislation in 2004. The NBS panel was recently expanded to include a number of additional hereditary congenital conditions. Expertise and experiences from other NBS programs already screening for hemoglobinopathies were essential to its successful integration into the ongoing dried bloodspot NBS program in the Philippines. Building on clinical experiences and population data from Filipinos born in California, USA, hemoglobinopathies (including thalassemias) were selected for inclusion in the expanded screening panel. Hemoglobinopathy NBS, using high performance liquid chromatography, was implemented in a stepwise manner into the seven regional NBS screening laboratories. A central university laboratory provides confirmatory testing using both capillary electrophoresis and molecular methodologies. NBS results indicating carriers are followed up with educational fact sheets, while results of presumptive disease are referred for confirmatory testing and follow-up with a hematologist. Long-term care is provided through newborn screening continuity clinics across the country. Hemoglobinopathy NBS is now included in the national insurance package and screening uptake continues to increase nationally, exceeding 90% of all newborns in 7400+ hospitals and birthing centers nationwide prior to the COVID-19 pandemic.

Indexed as

hemoglobinopathyHPLCnewborn screeningPhilippinesthalassemia

Identifiers

PMID34204320
PMCPMC8293152
OpenAlexW3171805432

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.