Evidence map›Paper›PMID 34204265›Full record

ArticleInternational journal of molecular sciences2021

Soluble Cytoplasmic Expression and Purification of Immunotoxin HER2(scFv)-PE24B as a Maltose Binding Protein Fusion.

Sangsu Park, Minh Quan Nguyen, Huynh Kim Khanh Ta, Minh Tan Nguyen, Gunsup Lee, Chong Jai Kim, Yeon Jin Jang, Han Choe

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 18 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 1 institution in 2 countries.

Sangsu ParkDepartment of Physiology, Bio-Medical Institute of Technology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
Minh Quan NguyenDepartment of Physiology, Bio-Medical Institute of Technology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
Huynh Kim Khanh TaDepartment of Physiology, Bio-Medical Institute of Technology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
Minh Tan NguyenDepartment of Physiology, Bio-Medical Institute of Technology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
Gunsup LeeR&D Center, Fatiabgen Co., Ltd., Seoul 05855, Korea.
Chong Jai KimDepartment of Pathology, Asan-Minnesota Institute for Innovating Transplantation, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.
Yeon Jin JangDepartment of Physiology, Bio-Medical Institute of Technology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.ORCID 0000-0001-7350-5534
Han ChoeDepartment of Physiology, Bio-Medical Institute of Technology, University of Ulsan College of Medicine, Asan Medical Center, Seoul 05505, Korea.ORCID 0000-0003-4604-647X
Ulsan College · KR

Funding

Asan Institute for Life Sciences, Asan Medical Center 2020-IL0020-03National Research Foundation of Korea NRF-2015K1A4A3046807 and KNRF-2019067449
6 · The paper itself

Abstract

Human epidermal growth factor receptor 2 (HER-2) is overexpressed in many malignant tumors. The anti-HER2 antibody trastuzumab has been approved for treating HER2-positive early and metastatic breast cancers.

Indexed as

ADP Ribose TransferasesBacterial ToxinsExotoxinsMaltose-Binding ProteinsSingle-Chain AntibodiesVirulence FactorsAntineoplastic Agents, ImmunologicalCell Line, TumorCell SurvivalDose-Response Relationship, DrugErb-b2 Receptor Tyrosine KinasesEscherichia coliGene ExpressionGenetic EngineeringGenetic VectorsHumansADP Ribose TransferasesAntineoplastic Agents, ImmunologicalBacterial ToxinsERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesExotoxinsImmunotoxinsMaltose-Binding ProteinsPseudomonas aeruginosa Exotoxin ARecombinant Fusion ProteinsSingle-Chain AntibodiesVirulence FactorscytotoxicityHER2(scFv)-PE24Bimmunotoxinmaltose binding proteinprotein expressionprotein purificationPseudomonas aeruginosaPseudomonas exotoxin Atrastuzumab

Identifiers

PMID34204265
PMCPMC8234717
OpenAlexW3169258202

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.