Evidence map›Paper›PMID 34204228›Full record

ReviewInternational journal of molecular sciences2021

The Muscle-Brain Axis and Neurodegenerative Diseases: The Key Role of Mitochondria in Exercise-Induced Neuroprotection.

Johannes Burtscher, Grégoire P Millet, Nicolas Place, Bengt Kayser, Nadège Zanou

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 89 papers, 2 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
89citing papers in PubMed, 2 pooled it
6.2field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

89 citing papers in PubMed, 2 syntheses or guidelines pooled it, 128 citations in OpenAlex.

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29 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Johannes BurtscherInstitute of Sport Sciences, University of Lausanne, CH-1015 Lausanne, Switzerland.ORCID 0000-0002-2889-0151
Grégoire P MilletInstitute of Sport Sciences, University of Lausanne, CH-1015 Lausanne, Switzerland.ORCID 0000-0001-8081-4423
Nicolas PlaceInstitute of Sport Sciences, University of Lausanne, CH-1015 Lausanne, Switzerland.ORCID 0000-0001-9044-0621
Bengt KayserInstitute of Sport Sciences, University of Lausanne, CH-1015 Lausanne, Switzerland.ORCID 0000-0002-9776-7501
Nadège ZanouInstitute of Sport Sciences, University of Lausanne, CH-1015 Lausanne, Switzerland.ORCID 0000-0001-6626-3127
University of Lausanne · CH

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Regular exercise is associated with pronounced health benefits. The molecular processes involved in physiological adaptations to exercise are best understood in skeletal muscle. Enhanced mitochondrial functions in muscle are central to exercise-induced adaptations. However, regular exercise also benefits the brain and is a major protective factor against neurodegenerative diseases, such as the most common age-related form of dementia, Alzheimer's disease, or the most common neurodegenerative motor disorder, Parkinson's disease. While there is evidence that exercise induces signalling from skeletal muscle to the brain, the mechanistic understanding of the crosstalk along the muscle-brain axis is incompletely understood. Mitochondria in both organs, however, seem to be central players. Here, we provide an overview on the central role of mitochondria in exercise-induced communication routes from muscle to the brain. These routes include circulating factors, such as myokines, the release of which often depends on mitochondria, and possibly direct mitochondrial transfer. On this basis, we examine the reported effects of different modes of exercise on mitochondrial features and highlight their expected benefits with regard to neurodegeneration prevention or mitigation. In addition, knowledge gaps in our current understanding related to the muscle-brain axis in neurodegenerative diseases are outlined.

Indexed as

Disease SusceptibilitySignal TransductionAnimalsBiomarkersBrainCytokinesEnergy MetabolismExerciseHumansMitochondriaMitochondrial DynamicsMuscle, SkeletalNeurodegenerative DiseasesNeuroprotectionOxidative StressReactive Oxygen SpeciesBiomarkersCytokinesReactive Oxygen Speciesbrainexercisemitochondriamusclemyokinesneurodegeneration

Identifiers

PMID34204228
PMCPMC8235687
OpenAlexW3174834337

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.