ArticleInternational journal of molecular sciences2021
Differential Regulation of Gonadotropins as Revealed by Transcriptomes of Distinct LH and FSH Cells of Fish Pituitary.
Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
25 citing papers in PubMed, 45 citations in OpenAlex.
- Effects of IGF1 and GnRH on gonadotropin subunits in the pituitary cells of the Indian freshwater catfish, Heteropneustes fossilis (Bloch).Fish physiology and biochemistry · 2026Article
- Anatomy of the hypothalamic-pituitary axis and buccal lobe in the holocephalan Callorhinchus callorynchus.Cell and tissue research · 2026Article
- Three cholecystokinin receptors differentially regulate reproduction, digestion, lipid metabolism and growth in medaka.The Journal of endocrinology · 2026Article
- Molecular Mechanisms of Dysregulated LH and FSH Secretion in Human Reproductive Failure.Biomedicines · 2026Review
- Environmental and Physiological Regulation of Reproduction in the Goldfish: Gonadal Development, Maturation, and Spawning Behavior: A Review.Animals : an open access journal from MDPI · 2026Review
- Interaction Between Photoperiod and Gonadal Feedback onZoological studies · 2026Article
- Differential hypothalamic regulation of FSH and LH secretion from the fish pituitary by GnRH and CCK.Reproduction (Cambridge, England) · 2025Article
- Emerging Perspectives on Gonadotropin Regulation in Vertebrates Revealed by the Discovery of FSH-RH in Teleosts.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025Review
- Cholecystokinin (CCK) Is a Mediator Between Nutritional Intake and Gonadal Development in Teleosts.Cells · 2025Article
- The satiety hormone cholecystokinin gates reproduction in fish by controlling gonadotropin secretion.eLife · 2024Article
- GnRH-Gonadotropes Interactions Revealed by Pituitary Single-cell Transcriptomics in Zebrafish.Endocrinology · 2024Article
- Effect of Salinity and Salmon Pituitary Extract on the Expression of Reproduction and/or Salinity-Related Genes in the Pituitary Cells of Japaneses Eel.Development & reproduction · 2024Article
- Combined Pituitary Hormone Deficiency inInternational journal of molecular sciences · 2024Article
- Identification of the FSH-RH as the other gonadotropin-releasing hormone.Nature communications · 2024Article
- Characterization of the somatostatin system in tilapia: implications for growth and reproduction.Frontiers in endocrinology · 2024Article
- A delayed and unsynchronized ovary development as revealed by transcriptome of brain and pituitary ofFrontiers in molecular biosciences · 2024Article
- Expression and localization of HPG axis-related genes in Carassius auratus with different ploidy.Frontiers in endocrinology · 2024Article
- Extraordinary variability in gene activation and repression programs during gonadal sex differentiation across vertebrates.Frontiers in cell and developmental biology · 2024Article
- Single cell genomics as a transformative approach for aquaculture research and innovation.Reviews in aquaculture · 2023Review
- Vitamin E Ameliorates Impaired Ovarian Development, Oxidative Stress, and Disrupted Lipid Metabolism inAntioxidants (Basel, Switzerland) · 2023Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
From mammals to fish, reproduction is driven by luteinizing hormone (LH) and follicle-stimulating hormone (FSH) temporally secreted from the pituitary gland. Teleost fish are an excellent model for addressing the unique regulation and function of each gonadotropin cell since, unlike mammals, they synthesize and secrete LH and FSH from distinct cells. Only very distant vertebrate classes (such as fish and birds) demonstrate the mono-hormonal strategy, suggesting a potential convergent evolution. Cell-specific transcriptome analysis of double-labeled transgenic tilapia expressing GFP and RFP in LH or FSH cells, respectively, yielded genes specifically enriched in each cell type, revealing differences in hormone regulation, receptor expression, cell signaling, and electrical properties. Each cell type expresses a unique GPCR signature that reveals the direct regulation of metabolic and homeostatic hormones. Comparing these novel transcriptomes to that of rat gonadotrophs revealed conserved genes that might specifically contribute to each gonadotropin activity in mammals, suggesting conserved mechanisms controlling the differential regulation of gonadotropins in vertebrates.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.