ReviewInternational journal of molecular sciences2021
Granulomatous Inflammation in ANCA-Associated Vasculitis.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers, 2 of them syntheses that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
17 citing papers in PubMed, 2 syntheses or guidelines pooled it, 40 citations in OpenAlex.
- Hepatic granulomas as a manifestation of ANCA-associated vasculitis:a systematic review.Frontiers in immunology · 2026Pooled it
- Ocular and orbital manifestations of granulomatosis with polyangiitis: a systematic review of published cases.Romanian journal of ophthalmologyPooled it
- The theory of the inflammatory ecosystem.Science China. Life sciences · 2026Review
- Immunosuppression and Surgery-Free Interval in Granulomatosis With Polyangiitis Airway Stenosis.The Laryngoscope · 2026Article
- Interstitial granulomatous dermatitis secondary to microscopic polyangiitis.JAAD case reports · 2026Article
- Assessment of cardiovascular risk in patients with ANCA-associated vasculitis: A systematic review and meta-analysis.International journal of cardiology. Cardiovascular risk and prevention · 2024Review
- Recurrent Coronary Vasospasm in a 50-Year-Old Woman with Granulomatous Polyangiitis: A Case Report.Journal of inflammation research · 2024Article
- Antimyeloperoxidase antibodies modulate inflammatory responses and activate profibrotic pathways in human monocytes.Journal of autoimmunity · 2023Article
- Diminished PD-L1 regulation along with dysregulated T lymphocyte subsets and chemokine in ANCA-associated vasculitis.Clinical and experimental medicine · 2023Article
- Combination Treatment of Locoregionally Aggressive Granulomatosis with Polyangiitis and Cranial Base Infiltration.Brain sciences · 2023Article
- Proteinase 3 promotes formation of multinucleated giant cells and granuloma-like structures in patients with granulomatosis with polyangiitis.Annals of the rheumatic diseases · 2023Article
- EGPA Phenotyping: Not Only ANCA, but Also Eosinophils.Biomedicines · 2023Article
- Granulomatous polyangiitis involving the fourth ventricle: Report of a rare case and a literature review.Open life sciences · 2023Article
- Article
- [Update on etiopathogenesis of small vessel vasculitis].Zeitschrift fur Rheumatologie · 2022Review
- Immunogenic cell death as driver of autoimmunity in granulomatosis with polyangiitis.Frontiers in immunology · 2022Review
- Identification of Hub Biomarkers and Immune-Related Pathways Participating in the Progression of Antineutrophil Cytoplasmic Antibody-Associated Glomerulonephritis.Frontiers in immunology · 2021Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 4 institutions in 1 country.
Funding
Abstract
ANCA-associated vasculitis (AAV) comprises granulomatosis with polyangiitis (GPA), microscopic polyangiitis (MPA), and eosinophilic granulomatosis with polyangiitis (EGPA). While systemic vasculitis is a hallmark of all AAV, GPA is characterized by extravascular granulomatous inflammation, preferentially affecting the respiratory tract. The mechanisms underlying the emergence of neutrophilic microabscesses; the appearance of multinucleated giant cells; and subsequent granuloma formation, finally leading to scarred or destroyed tissue in GPA, are still incompletely understood. This review summarizes findings describing the presence and function of molecules and cells contributing to granulomatous inflammation in the respiratory tract and to renal inflammation observed in GPA. In addition, factors affecting or promoting the development of granulomatous inflammation such as microbial infections, the nasal microbiome, and the release of damage-associated molecular patterns (DAMP) are discussed. Further, on the basis of numerous results, we argue that, in situ, various ways of exposure linked with a high number of infiltrating proteinase 3 (PR3)- and myeloperoxidase (MPO)-expressing leukocytes lower the threshold for the presentation of an altered PR3 and possibly also of MPO, provoking the local development of ANCA autoimmune responses, aided by the formation of ectopic lymphoid structures. Although extravascular granulomatous inflammation is unique to GPA, similar molecular and cellular patterns can be found in both the respiratory tract and kidney tissue of GPA and MPA patients; for example, the antimicrobial peptide LL37, CD163
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.