Evidence map›Paper›PMID 34204109›Full record

ArticleGenes2021

Eun-Gyung Lee, Sunny Chen, Lesley Leong, Jessica Tulloch, Chang-En Yu

Open access · goldAbstract read
In one paragraph

Article in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
26citing papers in PubMed, 3 pooled it
2.5field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

26 citing papers in PubMed, 3 syntheses or guidelines pooled it, 38 citations in OpenAlex.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. New Genetic Associations Between Alzheimer's Disease and Its Key Risk Factors.Psychogeriatrics : the official journal of the Japanese Psychogeriatric Society · 2026
    Article
  5. Article
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Article
  17. International journal of molecular sciences · 2023
    Article
  18. Article
  19. International journal of molecular sciences · 2023
    Article
  20. Alzheimer's Disease: An Updated Overview of Its Genetics.International journal of molecular sciences · 2023
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Eun-Gyung LeeGeriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA.
Sunny ChenGeriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA.ORCID 0000-0002-5230-2823
Lesley LeongGeriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA.
Jessica TullochGeriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA.
Chang-En YuGeriatric Research, Education, and Clinical Center, VA Puget Sound Health Care System, Seattle, WA 98108, USA.
VA Puget Sound Health Care System · USUniversity of Washington · US

Funding

APOE Gene-Based Haplotype Study in Alzeheimer's DiseaseR21AG024486 · NIA · UNIVERSITY OF WASHINGTON · PI YU, CHANG-EN · 2004 to 2005
$225k
The role of APOE locus genes regulation in Alzheimer's diseaseI01BX000933 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI YU, CHANG-EN · 2011 to 2024
–
Defining high- and low-risk APOE ε4 haplotypes for Alzheimer’s diseaseI01BX004823 · VA · VA PUGET SOUND HEALTHCARE SYSTEM · PI YU, CHANG-EN · 2021 to 2025
–
BLRD VA I01 BX000933BLRD VA I01 BX004823NIA NIH HHS R21 AG024486
6 · The paper itself

Abstract

Increasing evidence suggests that the Translocase of Outer Mitochondria Membrane 40 (

Indexed as

AgedAged, 80 and overAlzheimer DiseaseBrainCell LineCells, CulturedFemaleGene DosageHumansMaleMembrane Potential, MitochondrialMembrane Transport ProteinsMitochondriaMitochondrial Precursor Protein Import Complex ProteinsOxidative StressRNA, MessengerMembrane Transport ProteinsMitochondrial Precursor Protein Import Complex ProteinsRNA, MessengerTOMM40 protein, humanAlzheimer’s diseasemitochondrial dysfunctionpseudogeneRNA transcriptionTOMM40 gene

Identifiers

PMID34204109
PMCPMC8226536
OpenAlexW3172041599

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.