Evidence map›Paper›PMID 34204055›Full record

ArticleNutrients2021

Matcha Green Tea Alleviates Non-Alcoholic Fatty Liver Disease in High-Fat Diet-Induced Obese Mice by Regulating Lipid Metabolism and Inflammatory Responses.

Jihong Zhou, Yueer Yu, Lejia Ding, Ping Xu, Yuefei Wang

Open access · goldAbstract read
In one paragraph

Article in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.

0numbers the graph read from it
0cells of the map it votes in
23citing papers in PubMed
5.3field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

23 citing papers in PubMed, 44 citations in OpenAlex.

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  18. The alleviating effect ofFrontiers in pharmacology · 2023
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Jihong ZhouTea Research Institute, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0003-2315-8612
Yueer YuTea Research Institute, Zhejiang University, Hangzhou 310058, China.
Lejia DingTea Research Institute, Zhejiang University, Hangzhou 310058, China.
Ping XuTea Research Institute, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0003-1599-7408
Yuefei WangTea Research Institute, Zhejiang University, Hangzhou 310058, China.ORCID 0000-0002-0278-4625
Tea Research Institute · CN

Funding

China Postdoctoral Science Foundation 2020M681868
6 · The paper itself

Abstract

Lately, matcha green tea has gained popularity as a beverage and food additive. It has proved to be effective in preventing obesity and related metabolic syndromes. However, the underlying mechanisms of its control effects against non-alcoholic fatty liver disease (NAFLD) are complicated and remain elusive. In the present study, we performed an in vivo experiment using male C57BL/6 mice fed with a high-fat diet and simultaneously treated with matcha for six weeks. Serum biochemical parameters, histological changes, lipid accumulation, inflammatory cytokines, and relevant indicators were examined. Dietary supplementation of matcha effectively prevented excessive accumulation of visceral and hepatic lipid, elevated blood glucose, dyslipidemia, abnormal liver function, and steatosis hepatitis. RNA sequencing analyses of differentially expressed genes in liver samples indicated that matcha treatment decreased the activity of lipid droplet-associated proteins and increased the activity of cytochrome P450 enzymes, suggesting improved metabolic capacity and liver function. The current study provided evidence for new dietary strategies based on matcha supplementation to ameliorate lipotoxicity-induced obesity and NALFD.

Indexed as

TeaAnimalsAntioxidantsBlood GlucoseCytochrome P-450 Enzyme SystemDietary SupplementsDiet, High-FatDisease Models, AnimalDyslipidemiasInflammationLipid MetabolismLiverLiver Function TestsMaleMiceMice, Inbred C57BLAntioxidantsBlood GlucoseCytochrome P-450 Enzyme SystemTeacytochrome P450fatty toxicitylipid droplets-associated proteinsmatcha green teanonalcoholic fatty liver diseasenonalcoholic steatohepatitis

Identifiers

PMID34204055
PMCPMC8226714
OpenAlexW3171437463

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.