Evidence map›Paper›PMID 34204051›Full record

SynthesisNutrients2021

Carotenoids in the Management of Glaucoma: A Systematic Review of the Evidence.

Drake W Lem, Dennis L Gierhart, Pinakin Gunvant Davey

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed, 1 pooled it
4.7field-weighted citation impact, top 4% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 1 synthesis or guideline pooled it, 30 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Drake W LemCollege of Optometry, Western University of Health Sciences, 309 E Second St, Pomona, CA 91766, USA.ORCID 0000-0003-1060-9162
Dennis L GierhartZeaVision, LLC, Chesterfield, MO 630005, USA.
Pinakin Gunvant DaveyCollege of Optometry, Western University of Health Sciences, 309 E Second St, Pomona, CA 91766, USA.ORCID 0000-0002-6683-7052
Western University of Health Sciences · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Primary open-angle glaucoma (POAG) remains a leading cause of irreversible blindness globally. Recent evidence further substantiates sustained oxidative stress, and compromised antioxidant defenses are key drivers in the onset of glaucomatous neurodegeneration. Overwhelming oxidative injury is likely attributed to compounding mitochondrial dysfunction that worsens with age-related processes, causing aberrant formation of free radical species. Thus, a compromised systemic antioxidant capacity exacerbates further oxidative insult in glaucoma, leading to apoptosis, neuroinflammation, and subsequent tissue injury. The purpose of this systematic review is to investigate the neuroprotective benefits of the macular carotenoids lutein, zeaxanthin, and

Indexed as

Dietary SupplementsAntioxidantsCarotenoidsGlaucoma, Open-AngleHumansLuteinMacular PigmentOxidative StressVisual AcuityZeaxanthinsAntioxidantsCarotenoidsLuteinMacular Pigmentmeso-zeaxanthinZeaxanthinscarotenoidsglaucomaluteinmacular pigmentmacular pigment optical densitymeso-zeaxanthinMPODprimary open-angle glaucomaretinal neurodegenerationzeaxanthin

Identifiers

PMID34204051
PMCPMC8228567
OpenAlexW3165958248

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.