Evidence map›Paper›PMID 34204046›Full record

ArticleMarine drugs2021

Genome Mining for Antimicrobial Compounds in Wild Marine Animals-Associated Enterococci.

Janira Prichula, Muriel Primon-Barros, Romeu C Z Luz, Ícaro M S Castro, Thiago G S Paim, Maurício Tavares, Rodrigo Ligabue-Braun, Pedro A d'Azevedo, Jeverson Frazzon, Ana P G Frazzon and 2 more

Open access · goldAbstract read
In one paragraph

Article in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.

0numbers the graph read from it
0cells of the map it votes in
15citing papers in PubMed
1.6field-weighted citation impact, top 16% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

15 citing papers in PubMed, 27 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Article
  5. Review
  6. Review
  7. Genomic Characterization and Safety Evaluation ofAntibiotics (Basel, Switzerland) · 2025
    Article
  8. Mining the UniProtKB/Swiss-Prot database for antimicrobial peptides.Protein science : a publication of the Protein Society · 2025
    Article
  9. Article
  10. Article
  11. Genomic insights intoMicrobial genomics · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 3 institutions in 2 countries.

Janira PrichulaGram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.ORCID 0000-0002-6767-8890
Muriel Primon-BarrosGram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.ORCID 0000-0002-7117-7714
Romeu C Z LuzGram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
Ícaro M S CastroGram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
Thiago G S PaimGram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
Maurício TavaresCentro de Estudos Costeiros, Limnológicos e Marinhos (CECLIMAR), Universidade Federal do Rio Grande do Sul (UFRGS), Campus Litoral Norte, Imbé 95625-000, RS, Brazil.
Rodrigo Ligabue-BraunDepartment of Pharmacosciences, UFCSPA, Porto Alegre 90050-170, RS, Brazil.ORCID 0000-0002-2555-9754
Pedro A d'AzevedoGram-Positive Cocci Laboratory, Federal University of Health Sciences of Porto Alegre (UFCSPA), Porto Alegre 90050-170, RS, Brazil.
Jeverson FrazzonFood Science Institute, UFRGS, Porto Alegre 90035-003, RS, Brazil.
Ana P G FrazzonDepartment of Microbiology, Immunology and Parasitology, UFRGS, Porto Alegre 90050-170, RS, Brazil.ORCID 0000-0002-1029-5776
Adriana SeixasDepartment of Pharmacosciences, UFCSPA, Porto Alegre 90050-170, RS, Brazil.
Michael S GilmoreMassachusetts Eye and Ear Infirmary, Department of Ophthalmology, Harvard Medical School, Boston, MA 02114, USA.
Universidade Federal de Ciências da Saúde de Porto Alegre · BRUniversidade Federal do Rio Grande do Sul · BRMassachusetts Eye and Ear Infirmary · US

Funding

Conselho Nacional de Desenvolvimento Científico e Tecnológico 40788/2018-4NIH HHS AI083214
6 · The paper itself

Abstract

New ecosystems are being actively mined for new bioactive compounds. Because of the large amount of unexplored biodiversity, bacteria from marine environments are especially promising. Further, host-associated microbes are of special interest because of their low toxicity and compatibility with host health. Here, we identified and characterized biosynthetic gene clusters encoding antimicrobial compounds in host-associated enterococci recovered from fecal samples of wild marine animals remote from human-affected ecosystems. Putative biosynthetic gene clusters in the genomes of 22

Indexed as

Anti-Infective AgentsProbioticsTerpenesAnimalsAnimals, WildAquatic OrganismsBacteriocinsComputational BiologyEnterococcusFecesMultigene FamilyAnti-Infective AgentsBacteriocinsTerpenesbacteriocinsenterococcigenome-wide analysisprobioticswild marine species

Identifiers

PMID34204046
PMCPMC8229437
OpenAlexW3119866110

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.