Evidence map›Paper›PMID 34204026›Full record

ArticleInternational journal of molecular sciences2021

Docking-Based 3D-QSAR Studies for 1,3,4-oxadiazol-2-one Derivatives as FAAH Inhibitors.

Agata Zięba, Tuomo Laitinen, Jayendra Z Patel, Antti Poso, Agnieszka A Kaczor

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.3field-weighted citation impact, top 10% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 17 citations in OpenAlex.

  1. 2-Phenylcyclopropylmethylamine (PCPMA) Derivatives as DInternational journal of molecular sciences · 2025
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  7. Molecular Modeling Studies ofInternational journal of molecular sciences · 2021
    Article
  8. In Silico Screening of Novel α1-GABAInternational journal of molecular sciences · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 3 countries.

Agata ZiębaDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, PL-20059 Lublin, Poland.ORCID 0000-0002-8515-7482
Tuomo LaitinenSchool of Pharmacy, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0003-1539-2142
Jayendra Z PatelDivision of Pharmaceutical Chemistry and Technology, University of Helsinki, FI-00790 Helsinki, Finland.ORCID 0000-0002-2562-1888
Antti PosoSchool of Pharmacy, University of Eastern Finland, FI-70211 Kuopio, Finland.ORCID 0000-0003-4196-4204
Agnieszka A KaczorDepartment of Synthesis and Chemical Technology of Pharmaceutical Substances with Computer Modeling Laboratory, Faculty of Pharmacy, Medical University of Lublin, PL-20059 Lublin, Poland.ORCID 0000-0001-8679-9623
Medical University of Lublin · PLUniversity of Eastern Finland · FIUniversity of Helsinki · FI

Funding

Uniwersytet Medyczny w Lublinie DS33
6 · The paper itself

Abstract

This work aimed to construct 3D-QSAR CoMFA and CoMSIA models for a series of 31 FAAH inhibitors, containing the 1,3,4-oxadiazol-2-one moiety. The obtained models were characterized by good statistical parameters: CoMFA Q

Indexed as

Molecular Docking SimulationQuantitative Structure-Activity RelationshipHydrogen BondingInhibitory Concentration 50OxadiazolesReproducibility of Results1,3,4-oxadiazol-2(3H)-oneOxadiazoles3D QSARCoMFA modelCoMSIA modelFAAH inhibitors

Identifiers

PMID34204026
PMCPMC8201265
OpenAlexW3172490387

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.