Evidence map›Paper›PMID 34203974›Full record

ReviewInternational journal of molecular sciences2021

The Diverse Roles of TNNI3K in Cardiac Disease and Potential for Treatment.

Caroline Pham, Noelia Muñoz-Martín, Elisabeth M Lodder

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.

0numbers the graph read from it
0cells of the map it votes in
12citing papers in PubMed
2.2field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

12 citing papers in PubMed, 19 citations in OpenAlex.

  1. Genetic loci responsible for atrioventricular block in children.Frontiers in cell and developmental biology · 2026
    Review
  2. Article
  3. Article
  4. Review
  5. Article
  6. Article
  7. Article
  8. Expression Levels of theInternational journal of molecular sciences · 2023
    Article
  9. Genetic Burden ofCirculation. Genomic and precision medicine · 2023
    Article
  10. Review
  11. Article
  12. Whole-Exome Sequencing Identifies a Novel Variant (c.1538T > C) ofFrontiers in cardiovascular medicine · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

3 authors at 1 institution in 1 country.

Caroline PhamDepartment of Clinical and Experimental Cardiology, Heart Center, University of Amsterdam, Amsterdam UMC, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-8465-2978
Noelia Muñoz-MartínDepartment of Clinical and Experimental Cardiology, Heart Center, University of Amsterdam, Amsterdam UMC, 1105 AZ Amsterdam, The Netherlands.
Elisabeth M LodderDepartment of Clinical and Experimental Cardiology, Heart Center, University of Amsterdam, Amsterdam UMC, 1105 AZ Amsterdam, The Netherlands.ORCID 0000-0001-6017-3796
Amsterdam University Medical Centers · NL

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek VIDI-91718361Netherlands CardioVascular Research Initiative CVON2017-15 RESCUED
6 · The paper itself

Abstract

In the two decades since the discovery of TNNI3K it has been implicated in multiple cardiac phenotypes and physiological processes. TNNI3K is an understudied kinase, which is mainly expressed in the heart. Human genetic variants in

Indexed as

AnimalsDisease Models, AnimalHeart DiseasesHumansMolecular Targeted TherapyProtein Serine-Threonine KinasesRegenerationProtein Serine-Threonine Kinasescardiac regenerationcardiomyopathyconduction diseasehypertrophymyocardial infarctionphosphorylationsupraventricular arrhythmiasTNNI3K

Identifiers

PMID34203974
PMCPMC8232738
OpenAlexW3171858266

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.