ArticleMolecules (Basel, Switzerland)2021
Ethiopian Medicinal Plants Traditionally Used for the Treatment of Cancer; Part 3: Selective Cytotoxic Activity of 22 Plants against Human Cancer Cell Lines.
Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 26 citations in OpenAlex.
- In vitro cytotoxicity of medicinal plants used in prostate cancer management in Africa: a systematic review.Tropical medicine and health · 2026Review
- Phytochemical composition, in vitro antioxidant and antibacterial activities of Dorstenia barnimiana Schweinf leaf extracts.BMC complementary medicine and therapies · 2026Article
- Opportunities and Challenges of Integrating Ethiopian Traditional Medicine System Into Modern Medicine: A Narrative Review.TheScientificWorldJournal · 2026Review
- Targeting racial disparities in breast cancer: mechanistic insights and therapeutic potential of African medicinal plants.Medical oncology (Northwood, London, England) · 2025Review
- Exploring the anticancer potential of Hewittia malabarica through phytochemical analysis and molecular docking study.Scientific reports · 2025Article
- In Silico Molecular Docking Analysis, Cytotoxicity, and Antibacterial Activities of Constituents of Fruits ofACS omega · 2024Article
- Medicinal Plants Used by Oromo Community in Kofale District, West-Arsi Zone, Oromia Regional State, Ethiopia.Journal of experimental pharmacology · 2024Article
- Article
- A comprehensive review of the ethnomedicine, phytochemistry, pharmacological activities of the genusPharmaceutical biology · 2022Review
- In Vitro Cytotoxic Activity of African Plants: A Review.Molecules (Basel, Switzerland) · 2022Review
- Traditional and Phytochemical Bases of Herbs, Shrubs, Climbers, and Trees from Ethiopia for Their Anticancer Response.BioMed research international · 2022Review
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Authors and funding
10 authors at 3 institutions in 3 countries.
Funding
Abstract
Medicinal plants have been traditionally used to treat cancer in Ethiopia. However, very few studies have reported the in vitro anticancer activities of medicinal plants that are collected from different agro-ecological zones of Ethiopia. Hence, the main aim of this study was to screen the cytotoxic activities of 80% methanol extracts of 22 plants against human peripheral blood mononuclear cells (PBMCs), as well as human breast (MCF-7), lung (A427), bladder (RT-4), and cervical (SiSo) cancer cell lines. Active extracts were further screened against human large cell lung carcinoma (LCLC-103H), pancreatic cancer (DAN-G), ovarian cancer (A2780), and squamous cell carcinoma of the esophagus (KYSE-70) by using the crystal violet cell proliferation assay, while the vitality of the acute myeloid leukemia (HL-60) and histiocytic lymphoma (U-937) cell lines was monitored in the 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl-2
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