Evidence map›Paper›PMID 34203870›Full record

ReviewMarine drugs2021

Development of Marine-Derived Compounds for Cancer Therapy.

Weimin Zuo, Hang Fai Kwok

Abstract readReview
In one paragraph

Review in Marine drugs, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers.

0numbers the graph read from it
0cells of the map it votes in
30citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

30 citing papers in PubMed.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Weimin ZuoCancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macao.
Hang Fai KwokCancer Centre, Faculty of Health Sciences, University of Macau, Avenida de Universidade, Taipa, Macao.ORCID 0000-0002-6349-4517

Funding

Fundo para o Desenvolvimento das Ciências e da Tecnologia 0055/2019/A1Fundo para o Desenvolvimento das Ciências e da Tecnologia 019/2017/A1
6 · The paper itself

Abstract

Cancer has always been a threat to human health with its high morbidity and mortality rates. Traditional therapy, including surgery, chemotherapy and radiotherapy, plays a key role in cancer treatment. However, it is not able to prevent tumor recurrence, drug resistance and treatment side effects, which makes it a very attractive challenge to search for new effective and specific anticancer drugs. Nature is a valuable source of multiple pharmaceuticals, and most of the anticancer drugs are natural products or derived from them. Marine-derived compounds, such as nucleotides, proteins, peptides and amides, have also shed light on cancer therapy, and they are receiving a fast-growing interest due to their bioactive properties. Their mechanisms contain anti-angiogenic, anti-proliferative and anti-metastasis activities; cell cycle arrest; and induction of apoptosis. This review provides an overview on the development of marine-derived compounds with anticancer properties, both their applications and mechanisms, and discovered technologies.

Indexed as

AnimalsAntineoplastic AgentsApoptosisAquatic OrganismsBiological ProductsCarcinogenesisCell CycleClinical Trials as TopicDrug DevelopmentDrug DiscoveryHumansNeoplasmsUnited StatesUnited States Food and Drug AdministrationAntineoplastic AgentsBiological Productscancer therapymarine-derived compoundsmechanismtechnology

Identifiers

PMID34203870
PMCPMC8232666

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.