Evidence map›Paper›PMID 34203729›Full record

ReviewPlants (Basel, Switzerland)2021

A Comprehensive Overview on the Production of Vaccines in Plant-Based Expression Systems and the Scope of Plant Biotechnology to Combat against SARS-CoV-2 Virus Pandemics.

Manu Kumar, Nisha Kumari, Nishant Thakur, Shashi Kant Bhatia, Ganesh Dattatraya Saratale, Gajanan Ghodake, Bhupendra M Mistry, Hemasundar Alavilli, D S Kishor, Xueshi Du and 1 more

Open access · goldAbstract readReview
In one paragraph

Review in Plants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.

0numbers the graph read from it
0cells of the map it votes in
14citing papers in PubMed
4.2field-weighted citation impact, top 5% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

14 citing papers in PubMed, 33 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 5 institutions in 1 country.

Manu KumarDepartment of Life Science, College of Life Science and Biotechnology, Dongguk University, Seoul 10326, Korea.ORCID 0000-0003-3490-5062
Nisha KumariDepartment of Radiology, Seoul National University Hospital, Seoul National University College of Medicine, Seoul 03080, Korea.
Nishant ThakurDepartment of Hospital Pathology, Yeouido St. Mary's Hospital, College of Medicine, The Catholic University of Korea, 10, 63-ro, Yeongdeungpo-gu, Seoul 07345, Korea.ORCID 0000-0001-8761-0837
Shashi Kant BhatiaDepartment of Biological Engineering, College of Engineering, Konkuk University, 1 Hwayang-dong, Gwangjin-gu, Seoul 05029, Korea.ORCID 0000-0002-7688-6069
Ganesh Dattatraya SarataleDepartment of Food Science and Biotechnology, Dongguk University, Seoul 10326, Korea.ORCID 0000-0002-3874-4502
Gajanan GhodakeDepartment of Biological and Environmental Science, Dongguk University, Seoul 10326, Korea.ORCID 0000-0001-6527-3745
Bhupendra M MistryDepartment of Food Science and Biotechnology, Dongguk University, Seoul 10326, Korea.
Hemasundar AlavilliDepartment of Biochemistry and Molecular Biology, College of Medicine, Korea University, Seoul 02841, Korea.ORCID 0000-0003-1018-4416
D S KishorDepartment of Life Science, College of Life Science and Biotechnology, Dongguk University, Seoul 10326, Korea.ORCID 0000-0001-8704-6973
Xueshi DuDepartment of Life Science, College of Life Science and Biotechnology, Dongguk University, Seoul 10326, Korea.
Sang-Min ChungDepartment of Life Science, College of Life Science and Biotechnology, Dongguk University, Seoul 10326, Korea.
Dongguk University · KRKonkuk University · KRKorea University · KRSeoul National University Hospital · KRThe Catholic University of Korea Yeouido St. Mary's Hospital · KR

Funding

Dongguk University 2020-2022Korea Institute of Planning and Evaluation for Technology in Food, Agriculture, Forestry 317011-04-3-HD020
6 · The paper itself

Abstract

Many pathogenic viral pandemics have caused threats to global health; the COVID-19 pandemic is the latest. Its transmission is growing exponentially all around the globe, putting constraints on the health system worldwide. A novel coronavirus, severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), causes this pandemic. Many candidate vaccines are available at this time for COVID-19, and there is a massive international race underway to procure as many vaccines as possible for each country. However, due to heavy global demand, there are strains in global vaccine production. The use of a plant biotechnology-based expression system for vaccine production also represents one part of this international effort, which is to develop plant-based heterologous expression systems, virus-like particles (VLPs)-vaccines, antiviral drugs, and a rapid supply of antigen-antibodies for detecting kits and plant origin bioactive compounds that boost the immunity and provide tolerance to fight against the virus infection. This review will look at the plant biotechnology platform that can provide the best fight against this global pandemic.

Indexed as

bio-farmingCOVID-19 vaccinerespiratory disorderSARS-CoV-2 virusvaccine

Identifiers

PMID34203729
PMCPMC8232254
OpenAlexW3167651750

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.