Evidence map›Paper›PMID 34203675›Full record

ArticleInternational journal of molecular sciences2021

(-)-Englerin-A Has Analgesic and Anti-Inflammatory Effects Independent of TRPC4 and 5.

João de Sousa Valente, Khadija M Alawi, Sabah Bharde, Ali A Zarban, Xenia Kodji, Dibesh Thapa, Fulye Argunhan, Brentton Barrett, Istvan Nagy, Susan D Brain

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 50% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 4 citations in OpenAlex.

  1. Article
  2. Review
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 2 institutions in 2 countries.

João de Sousa ValenteSection of Vascular Biology and Inflammation, BHF Cardiovascular Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK.ORCID 0000-0003-1888-6324
Khadija M AlawiSection of Vascular Biology and Inflammation, BHF Cardiovascular Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK.
Sabah BhardeSection of Vascular Biology and Inflammation, BHF Cardiovascular Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK.
Ali A ZarbanSection of Vascular Biology and Inflammation, BHF Cardiovascular Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK.
Xenia KodjiSection of Vascular Biology and Inflammation, BHF Cardiovascular Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK.
Dibesh ThapaSection of Vascular Biology and Inflammation, BHF Cardiovascular Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK.ORCID 0000-0002-7435-5483
Fulye ArgunhanSection of Vascular Biology and Inflammation, BHF Cardiovascular Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK.ORCID 0000-0001-7616-2151
Brentton BarrettSection of Vascular Biology and Inflammation, BHF Cardiovascular Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK.
Istvan NagyNociception Group, Section of Anaesthetic, Pain Medicine and Intensive Care, Department of Surgery and Cancer, Imperial College London, London SW7 2AZ, UK.ORCID 0000-0003-3475-6108
Susan D BrainSection of Vascular Biology and Inflammation, BHF Cardiovascular Centre of Research Excellence, School of Cardiovascular Medicine and Sciences, King's College London, Franklin-Wilkins Building, London SE1 9NH, UK.ORCID 0000-0002-9684-8342
King's College London · GBImperial College London · GB

Funding

British Heart Foundation FS/19/42/34537British Heart Foundation PG/19/14/34268Versus Arthritis 21524Versus Arthritis ARUK21524
6 · The paper itself

Abstract

Recently, we found that the deletion of TRPC5 leads to increased inflammation and pain-related behaviour in two animal models of arthritis. (-)-Englerin A (EA), an extract from the East African plant

Indexed as

AnalgesicsAnimalsAnti-Inflammatory AgentsBehavior, AnimalCarrageenanCells, CulturedCobaltDisease Models, AnimalEdemaGanglia, SpinalHyperalgesiaInflammationMaleMiceMice, KnockoutPainAnalgesicsAnti-Inflammatory AgentsCarrageenanCobaltenglerin ASesquiterpenes, GuaianeTRPC Cation Channelscarrageenan(-)-Englerin AinflammationsynovitisTRPC4TRPC5

Identifiers

PMID34203675
PMCPMC8232259
OpenAlexW3166373503

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.