Evidence map›Paper›PMID 34203630›Full record

ArticleVaccines2021

Development of a Modular Vaccine Platform for Multimeric Antigen Display Using an Orthobunyavirus Model.

Andrea Aebischer, Kerstin Wernike, Patricia König, Kati Franzke, Paul J Wichgers Schreur, Jeroen Kortekaas, Marika Vitikainen, Marilyn Wiebe, Markku Saloheimo, Ronen Tchelet and 2 more

Open access · goldAbstract read
In one paragraph

Article in Vaccines, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed
7.3field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 27 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Review
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Review
  13. Review
  14. Article
  15. Article
  16. Article
  17. Article
  18. The Highly ProductiveVaccines · 2022
    Article
  19. Are There Hidden Genes in DNA/RNA Vaccines?Frontiers in immunology · 2022
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors at 5 institutions in 4 countries.

Andrea AebischerFriedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.
Kerstin WernikeFriedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0001-8071-0827
Patricia KönigFriedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.
Kati FranzkeFriedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.ORCID 0000-0003-0827-5407
Paul J Wichgers SchreurLaboratory of Virology, Wageningen Bioveterinary Research, 8221 RA Lelystad, The Netherlands.ORCID 0000-0001-9790-2438
Jeroen KortekaasLaboratory of Virology, Wageningen Bioveterinary Research, 8221 RA Lelystad, The Netherlands.ORCID 0000-0002-0329-0176
Marika VitikainenVTT Technical Research Centre of Finland Ltd., 02150 Espoo, Finland.
Marilyn WiebeVTT Technical Research Centre of Finland Ltd., 02150 Espoo, Finland.ORCID 0000-0002-4535-2427
Markku SaloheimoVTT Technical Research Centre of Finland Ltd., 02150 Espoo, Finland.
Ronen TcheletDyadic Netherland B.V., 6709 PA Wageningen, The Netherlands.
Jean-Christophe AudonnetBoehringer Ingelheim Animal Health, 69800 Saint-Priest, France.
Martin BeerFriedrich-Loeffler-Institut, 17493 Greifswald-Insel Riems, Germany.
Friedrich-Loeffler-Institut · DEVTT Technical Research Centre of Finland · FIWageningen University & Research · NLDépartement Santé Animale · FRDyadic (Netherlands) · NL

Funding

Innovative Medicines Initiative 115760
6 · The paper itself

Abstract

Emerging infectious diseases represent an increasing threat to human and animal health. Therefore, safe and effective vaccines that could be available within a short time frame after an outbreak are required for adequate prevention and control. Here, we developed a robust and versatile self-assembling multimeric protein scaffold particle (MPSP) vaccine platform using lumazine synthase (LS) from

Indexed as

C1 production hostemerging infectious diseaseepitopelumazine synthasemodular vaccineSchmallenberg virusSpyCatcher/SpyTagzoonosis

Identifiers

PMID34203630
PMCPMC8232151
OpenAlexW3171899244

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.