Evidence map›Paper›PMID 34203581›Full record

ArticleCancers2021

Differential Expression of

Rute M S M Pedrosa, Leonoor V Wismans, Renata Sinke, Marcel van der Weiden, Casper H J van Eijck, Johan M Kros, Dana A M Mustafa

Open access · goldAbstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.

0numbers the graph read from it
0cells of the map it votes in
9citing papers in PubMed
0.9field-weighted citation impact, top 27% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

9 citing papers in PubMed, 15 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Rute M S M PedrosaDepartment of Pathology, Erasmus University Medical Center, Wytemaweg 80, 3000 DR Rotterdam, The Netherlands.
Leonoor V WismansThe Tumor Immuno-Pathology (TIP) Laboratory, Erasmus University Medical Center, Wytemaweg 80, 3000 DR Rotterdam, The Netherlands.ORCID 0000-0002-7009-7034
Renata SinkeLaboratory of Pathology, Pathan BV, Kleiweg 500, 3045 PM Rotterdam, The Netherlands.
Marcel van der WeidenDepartment of Pathology, Erasmus University Medical Center, Wytemaweg 80, 3000 DR Rotterdam, The Netherlands.
Casper H J van EijckThe Tumor Immuno-Pathology (TIP) Laboratory, Erasmus University Medical Center, Wytemaweg 80, 3000 DR Rotterdam, The Netherlands.ORCID 0000-0002-9511-2157
Johan M KrosDepartment of Pathology, Erasmus University Medical Center, Wytemaweg 80, 3000 DR Rotterdam, The Netherlands.ORCID 0000-0002-4727-0724
Dana A M MustafaDepartment of Pathology, Erasmus University Medical Center, Wytemaweg 80, 3000 DR Rotterdam, The Netherlands.ORCID 0000-0003-0644-078X
Erasmus MC · NLPathoFinder (Netherlands) · NL

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundBrain metastasis is considered one of the major causes of mortality in breast cancer patients. To invade the brain, tumor cells need to pass the blood-brain barrier by mechanisms that are partially understood. In primary ER-negative breast cancers that developed brain metastases, we found that some of the differentially expressed genes play roles in the T cell response. The present study aimed to identify genes involved in the formation of brain metastasis independently from the T cell response.

methodPreviously profiled primary breast cancer samples were reanalyzed. Genes that were found to be differentially expressed were confirmed by RT-PCR and by immunohistochemistry using an independent cohort of samples.

results

conclusionThe overexpression of

Indexed as

blood-brain barrierBOCbrain metastasisER-breast cancerGJD3SPOCK2

Identifiers

PMID34203581
PMCPMC8232218
OpenAlexW3170905807

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.