Evidence map›Paper›PMID 34203562›Full record

ArticleMolecules (Basel, Switzerland)2021

Ditopic Aza-Scorpiand Ligands Interact Selectively with ds-RNA and Modulate the Interaction upon Formation of Zn

Lluís Guijarro, Álvaro Martínez-Camarena, Javier U Chicote, Antonio García-España, Enrique García-España, Mario Inclán, Begoña Verdejo, Jorge González-García

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.2field-weighted citation impact, top 51% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 2 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 1 country.

Lluís GuijarroInstituto de Ciencia Molecular (ICMol), Departamento de Química Inorgánica, Universidad de Valencia, C/Catedrático José Beltrán 2, 46980 Paterna, Spain.
Álvaro Martínez-CamarenaInstituto de Ciencia Molecular (ICMol), Departamento de Química Inorgánica, Universidad de Valencia, C/Catedrático José Beltrán 2, 46980 Paterna, Spain.ORCID 0000-0001-9910-6961
Javier U ChicoteInstitut d'Investigació Sanitària Pere Virgili (IISPV), Centro de I+D+I en Nutrición y Salud Avda. de la Universitat 1, 43204 Reus, Spain.
Antonio García-EspañaInstitut d'Investigació Sanitària Pere Virgili (IISPV), Centro de I+D+I en Nutrición y Salud Avda. de la Universitat 1, 43204 Reus, Spain.ORCID 0000-0002-9957-3161
Enrique García-EspañaInstituto de Ciencia Molecular (ICMol), Departamento de Química Inorgánica, Universidad de Valencia, C/Catedrático José Beltrán 2, 46980 Paterna, Spain.
Mario InclánInstituto de Ciencia Molecular (ICMol), Departamento de Química Inorgánica, Universidad de Valencia, C/Catedrático José Beltrán 2, 46980 Paterna, Spain.ORCID 0000-0003-0585-8842
Begoña VerdejoInstituto de Ciencia Molecular (ICMol), Departamento de Química Inorgánica, Universidad de Valencia, C/Catedrático José Beltrán 2, 46980 Paterna, Spain.ORCID 0000-0003-3022-1835
Jorge González-GarcíaInstituto de Ciencia Molecular (ICMol), Departamento de Química Inorgánica, Universidad de Valencia, C/Catedrático José Beltrán 2, 46980 Paterna, Spain.ORCID 0000-0001-8994-1779
Universitat de València · ESInstitut de Recerca Biomèdica Catalunya Sud · ES

Funding

Conselleria de Innovación, Universidades, Ciencia y Sociedad Digital, Generalitat Valenciana CIDEGENT/2018/015Ministerio de Ciencia e Innovación CTQ2016-78499-C6-1-RMinisterio de Ciencia e Innovación CTQ2017-90852-REDCMinisterio de Ciencia e Innovación MDM-15-0538Ministerio de Ciencia e Innovación PI16/00504Ministerio de Ciencia e Innovación PID2019-108643GA-I00Ministerio de Ciencia e Innovación PID2019-110751RB-I00
6 · The paper itself

Abstract

Nucleic acids are essential biomolecules in living systems and represent one of the main targets of chemists, biophysics, biologists, and nanotechnologists. New small molecules are continuously developed to target the duplex (ds) structure of DNA and, most recently, RNA to be used as therapeutics and/or biological tools. Stimuli-triggered systems can promote and hamper the interaction to biomolecules through external stimuli such as light and metal coordination. In this work, we report on the interaction with ds-DNA and ds-RNA of two aza-macrocycles able to coordinate Zn

Indexed as

Coordination ComplexesCytotoxinsZincAnimalsCell Line, TumorCell SurvivalChlorocebus aethiopsDNAHumansLigandsRNA, Double-StrandedVero CellsCoordination ComplexesCytotoxinsDNALigandsRNA, Double-StrandedZincaza-macrocycleDNA and RNA duplexeszinc complex

Identifiers

PMID34203562
PMCPMC8272215
OpenAlexW3174890014

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.