Evidence map›Paper›PMID 34203547›Full record

ArticleMolecules (Basel, Switzerland)2021

PLGA Nanoparticles Decorated with Anti-HER2 Affibody for Targeted Delivery and Photoinduced Cell Death.

Victoria Olegovna Shipunova, Anna Samvelovna Sogomonyan, Ivan Vladimirovich Zelepukin, Maxim Petrovich Nikitin, Sergey Mikhailovich Deyev

Open access · goldAbstract read
In one paragraph

Article in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.6field-weighted citation impact, top 9% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 39 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Victoria Olegovna ShipunovaShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.
Anna Samvelovna SogomonyanShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.
Ivan Vladimirovich ZelepukinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.
Maxim Petrovich NikitinShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.
Sergey Mikhailovich DeyevShemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, 16/10 Miklukho-Maklaya St., 117997 Moscow, Russia.ORCID 0000-0002-3952-0631
Moscow Institute of Physics and Technology · RUInstitute of Engineering Physics · RU

Funding

Russian Foundation for Basic Research 17-74-20146Russian Foundation for Basic Research 19-29-04012
6 · The paper itself

Abstract

The effect of enhanced permeability and retention is often not sufficient for highly effective cancer therapy with nanoparticles, and the development of active targeted drug delivery systems based on nanoparticles is probably the main direction of modern cancer medicine. To meet the challenge, we developed polymer PLGA nanoparticles loaded with fluorescent photosensitive xanthene dye, Rose Bengal, and decorated with HER2-recognizing artificial scaffold protein, affibody Z

Indexed as

Drug Delivery SystemsNanoparticlesPolylactic Acid-Polyglycolic Acid CopolymerRecombinant Fusion ProteinsA549 CellsAnimalsCell DeathCHO CellsCricetulusErb-b2 Receptor Tyrosine KinasesHumansNeoplasmsaffibody (ZHER2-342)2ERBB2 protein, humanErb-b2 Receptor Tyrosine KinasesPolylactic Acid-Polyglycolic Acid CopolymerRecombinant Fusion ProteinsaffibodyHER2nanoparticlesPLGAreactive oxygen speciesRose Bengaltargeted delivery

Identifiers

PMID34203547
PMCPMC8271481
OpenAlexW3176581805

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.