ArticleSensors (Basel, Switzerland)2021
Characterization of Pharmaceutical Tablets Using UV Hyperspectral Imaging as a Rapid In-Line Analysis Tool.
Article in Sensors (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed.
- Design and Development of an Automated Pipeline for Medical Hyperspectral Image Acquisition, Processing, and Fusion.Journal of imaging · 2026Article
- In-line multi-wavelength non-destructive pharma quality monitoring with ultrabroadband carbon nanotubes photo-thermoelectric imaging scanners.Light, science & applications · 2025Article
- Evaluation of Band Selection for Spectrum-Aided Visual Enhancer (SAVE) for Esophageal Cancer Detection.Journal of Cancer · 2025Article
- UV Hyperspectral Imaging with Xenon and Deuterium Light Sources: Integrating PCA and Neural Networks for Analysis of Different Raw Cotton Types.Journal of imaging · 2024Article
- Investigating Strategies to Enhance the Aqueous Solubility of Ketamine HCl for Intranasal Delivery.Pharmaceutics · 2024Article
- Rapid Detection of Cleanliness on Direct Bonded Copper Substrate by Using UV Hyperspectral Imaging.Sensors (Basel, Switzerland) · 2024Article
- Assessment of Directional-Hemispherical Reflectance of Tablets with Cefuroxime during Storage under Elevated Temperature and Ultraviolet Radiation.Sensors (Basel, Switzerland) · 2024Article
- Review
- Prediction of Honeydew Contaminations on Cotton Samples by In-Line UV Hyperspectral Imaging.Sensors (Basel, Switzerland) · 2022Article
- Challenges and Opportunities of Implementing Data Fusion in Process Analytical Technology-A Review.Molecules (Basel, Switzerland) · 2022Review
- A Review of Pharmaceutical Robot based on Hyperspectral Technology.Journal of intelligent & robotic systems · 2022Review
- Graphene Oxide-Doped Polymer Inclusion Membrane for Remediation of Pharmaceutical Contaminant of Emerging Concerns: Ibuprofen.Membranes · 2021Article
- UV Hyperspectral Imaging as Process Analytical Tool for the Characterization of Oxide Layers and Copper States on Direct Bonded Copper.Sensors (Basel, Switzerland) · 2021Article
Corrections and comments
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Authors and funding
5 authors.
Funding
Abstract
A laboratory prototype for hyperspectral imaging in ultra-violet (UV) region from 225 to 400 nm was developed and used to rapidly characterize active pharmaceutical ingredients (API) in tablets. The APIs are ibuprofen (IBU), acetylsalicylic acid (ASA) and paracetamol (PAR). Two sample sets were used for a comparison purpose. Sample set one comprises tablets of 100% API and sample set two consists of commercially available painkiller tablets. Reference measurements were performed on the pure APIs in liquid solutions (transmission) and in solid phase (reflection) using a commercial UV spectrometer. The spectroscopic part of the prototype is based on a pushbroom imager that contains a spectrograph and charge-coupled device (CCD) camera. The tablets were scanned on a conveyor belt that is positioned inside a tunnel made of polytetrafluoroethylene (PTFE) in order to increase the homogeneity of illumination at the sample position. Principal component analysis (PCA) was used to differentiate the hyperspectral data of the drug samples. The first two PCs are sufficient to completely separate all samples. The rugged design of the prototype opens new possibilities for further development of this technique towards real large-scale application.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.