Evidence map›Paper›PMID 34203467›Full record

ReviewInternational journal of molecular sciences2021

Chitinases and Chitinase-Like Proteins as Therapeutic Targets in Inflammatory Diseases, with a Special Focus on Inflammatory Bowel Diseases.

Marzena Mazur, Anna Zielińska, Marcin M Grzybowski, Jacek Olczak, Jakub Fichna

Open access · goldAbstract readReview
In one paragraph

Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 27 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
27citing papers in PubMed, 1 pooled it
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

27 citing papers in PubMed, 1 synthesis or guideline pooled it, 53 citations in OpenAlex.

  1. Chitinases as a potential diagnostic and prognostic biomarker for amyotrophic lateral sclerosis: a systematic review and meta-analysis.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2024
    Pooled it
  2. Article
  3. Application of Biomarkers in Spinal Muscular Atrophy.International journal of molecular sciences · 2025
    Review
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  13. [Role and mechanisms of CHI3L1 in coronary artery lesions in a mouse model of Kawasaki disease-like vasculitis].Zhongguo dang dai er ke za zhi = Chinese journal of contemporary pediatrics · 2023
    Article
  14. An overview of viral chitinases: General properties and biotechnological potential.Experimental biology and medicine (Maywood, N.J.) · 2023
    Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 1 country.

Marzena MazurDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, Poland.
Anna ZielińskaDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-9660-2158
Marcin M GrzybowskiOncoArendi Therapeutics SA, 02-089 Warsaw, Poland.
Jacek OlczakOncoArendi Therapeutics SA, 02-089 Warsaw, Poland.ORCID 0000-0001-9932-2373
Jakub FichnaDepartment of Biochemistry, Faculty of Medicine, Medical University of Lodz, 92-215 Lodz, Poland.ORCID 0000-0002-8443-4417
Medical University of Lodz · PLOncoArendi Therapeutics (Poland) · PL

Funding

Narodowe Centrum Badań i Rozwoju POIR.01.01.01-00-0552/16, acronym "YKL-40"Uniwersytet Medyczny w Lodzi #503/1-156-04/503-11-001-19-00 to JF
6 · The paper itself

Abstract

Chitinases belong to the evolutionarily conserved glycosyl hydrolase family 18 (GH18). They catalyze degradation of chitin to

Indexed as

AnimalsChitinase-3-Like Protein 1ChitinasesHumansInflammationInflammatory Bowel DiseasesChitinase-3-Like Protein 1Chitinaseschitinase inhibitorinflammatory bowel diseasesmammalian chitinaseYKL-40

Identifiers

PMID34203467
PMCPMC8268069
OpenAlexW3173832804

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.