Evidence map›Paper›PMID 34203409›Full record

ReviewDiseases (Basel, Switzerland)2021

The Potential Use of Vitamin C to Prevent Kidney Injury in Patients with COVID-19.

Feng Xu, Yawei Wen, Xinge Hu, Tiannan Wang, Guoxun Chen

Open access · goldAbstract readReview
In one paragraph

Review in Diseases (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed, 1 pooled it
1.7field-weighted citation impact, top 18% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 1 synthesis or guideline pooled it, 14 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Article
  5. Deciphering the immunoboosting potential of macro and micronutrients in COVID support therapy.Environmental science and pollution research international · 2022
    Review
  6. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 2 institutions in 2 countries.

Feng XuDepartment of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Yawei WenDepartment of Urology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China.
Xinge HuDepartment of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, USA.
Tiannan WangDepartment of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, USA.
Guoxun ChenDepartment of Nutrition, University of Tennessee at Knoxville, Knoxville, TN 37996, USA.ORCID 0000-0001-6226-4050
University of Tennessee at Knoxville · USFirst Affiliated Hospital of Zhengzhou University · CN

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The newly found SARS-CoV-2 has led to the pandemic of COVID-19, which has caused respiratory distress syndrome and even death worldwide. This has become a global public health crisis. Unfortunately, elders and subjects with comorbidities have high mortality rates. One main feature of COVID-19 is the cytokine storm, which can cause damage in cells and tissues including the kidneys. Here, we reviewed the current literature on renal impairments in patients with COVID-19 and analyzed the possible etiology and mechanisms. In addition, we investigated the potential use of vitamin C for the prevention of renal injury in those patients. It appears that vitamin C could be helpful to improve the outcomes of patients with COVID-19. Lastly, we discussed the possible protective effects of vitamin C on renal functions in COVID-19 patients with existing kidney conditions.

Indexed as

acute kidney injuryCOVID-19inflammatory cytokine stormoxidative stressvitamin C

Identifiers

PMID34203409
PMCPMC8293113
OpenAlexW3175260251

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.