ArticleAntioxidants (Basel, Switzerland)2021
Age and Sport Intensity-Dependent Changes in Cytokines and Telomere Length in Elite Athletes.
Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 38 citations in OpenAlex.
- Chronic inflammation mediates the relationship between physical activity and telomere length.GeroScience · 2026Article
- Age-Dependent Differences in Exercise Response Among Healthy Women: Impact on Inflammation, Lipids Profile and Glucose.Biomedicines · 2026Article
- Exercise-induced osteoimmune crosstalk: a virtuous cycle between bone remodeling and immune regulation.Frontiers in endocrinology · 2026Review
- Article
- Sport and longevity: an observational study of international athletes.GeroScience · 2025Observational
- Leukocyte telomere length and telomerase activity in Long COVID patients from Rio de Janeiro, Brazil.Memorias do Instituto Oswaldo Cruz · 2025Article
- Inflammation and cognitive performance in elite athletes: A cross-sectional study.Brain, behavior, & immunity - health · 2024Article
- Aging Processes Are Affected by Energy Balance: Focused on the Effects of Nutrition and Physical Activity on Telomere Length.Current nutrition reports · 2024Review
- Joint Effects of Exercise and Ramadan Fasting on Telomere Length: Implications for Cellular Aging.Biomedicines · 2024Article
- Differential Effects of Very-Low-Volume Exercise Modalities on Telomere Length, Inflammation, and Cardiometabolic Health in Obese Metabolic Syndrome Patients: A Subanalysis from Two Randomized Controlled Trials.Antioxidants (Basel, Switzerland) · 2023Article
- Time Spent Jogging/Running and Biological Aging in 4458 U.S. Adults: An NHANES Investigation.International journal of environmental research and public health · 2023Article
- Professional Athletes Maintain High TNF-Alpha or IFN-Gamma Related Inflammatory Status after Recovering from COVID-19 Infection without Developing a Neutralizing Antibody Response.Sports (Basel, Switzerland) · 2023Article
- Effect of Black Maca Supplementation on Inflammatory Markers and Physical Fitness in Male Elite Athletes.Nutrients · 2023Article
- Impact of Moderate Physical Activity on Inflammatory Markers and Telomere Length in Sedentary and Moderately Active Individuals with Varied Insulin Sensitivity.Journal of inflammation research · 2023Article
- Advancing athletic assessment by integrating conventional methods with cutting-edge biomedical technologies for comprehensive performance, wellness, and longevity insights.Frontiers in sports and active living · 2023Article
- The Influence of Diet and Physical Activity on Oxidative Stress in Romanian Females with Osteoarthritis.Nutrients · 2022Article
- A healthy lifestyle is positively associated with mental health and well-being and core markers in ageing.BMC medicine · 2022Article
- Benefits on Hematological and Biochemical Parameters of a High-Intensity Interval Training Program for a Half-Marathon in Recreational Middle-Aged Women Runners.International journal of environmental research and public health · 2022Article
- The Impact of Concussion, Sport, and Time in Season on Saliva Telomere Length in Healthy Athletes.Frontiers in sports and active living · 2022Article
- Effect of sera from elite athletes on cytokine secretion and insulin signaling in preadipocytes and skeletal muscle cells.Frontiers in molecular biosciences · 2022Article
Corrections and comments
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Authors and funding
9 authors at 3 institutions in 2 countries.
Funding
Abstract
backgroundExercise-associated immune response plays a crucial role in the aging process. The aim of this study is to investigate the effect of sport intensity on cytokine levels, oxidative stress markers and telomere length in aging elite athletes.
methodsIn this study, 80 blood samples from consenting elite athletes were collected for anti-doping analysis at an anti-doping laboratory in Italy (FMSI). Participants were divided into three groups according to their sport intensity: low-intensity skills and power sports (LI,
resultsTumor necrosis factor-alpha (TNF-α) was the only cytokine showing significantly higher concentration in older athletes, regardless of sport intensity. Interleukin (IL)-10 increased significantly in HI regardless of age group, whereas IL-6 concentration was higher in the older HI athletes. IL-8 showed a significant interaction with sport intensity in different age groups. Overall, significant positive correlations among levels of IL-6, IL-10, IL-8 and TNF-α were identified. The antioxidant catalase activity was positively correlated with levels of TNF-α. Telomere length increased significantly with sport intensity, especially in the younger group.
conclusionHI had longer telomeres and higher levels of pro- and anti-inflammatory cytokines, suggesting less aging in HI compared to low and moderate counterparts in association with heightened immune response. Investigation of the functional significance of these associations on the health and performance of elite athletes is warranted.
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