Evidence map›Paper›PMID 34203218›Full record

ArticleNanomaterials (Basel, Switzerland)2021

Drug-Releasing Antibacterial Coating Made from Nano-Hydroxyapatite Using the Sonocoating Method.

Khaled AbouAitah, Monika Bil, Elzbieta Pietrzykowska, Urszula Szałaj, Damian Fudala, Bartosz Woźniak, Justyna Nasiłowska, Anna Swiderska-Sroda, Maciej Lojkowski, Barbara Sokołowska and 2 more

Abstract read
In one paragraph

Article in Nanomaterials (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed, 1 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 1 synthesis or guideline pooled it.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

12 authors.

Khaled AbouAitahLaboratory of Nanostructures and Nanomedicine, Institute of High Pressure Physics, Polish Academy of Sciences, 29/37 Sokolowska Street, 01142 Warsaw, Poland.ORCID 0000-0001-8413-6738
Monika BilCentre for Advanced Materials and Technologies, Warsaw University of Technology, Poleczki 19, 02822 Warsaw, Poland.
Elzbieta PietrzykowskaLaboratory of Nanostructures and Nanomedicine, Institute of High Pressure Physics, Polish Academy of Sciences, 29/37 Sokolowska Street, 01142 Warsaw, Poland.
Urszula SzałajLaboratory of Nanostructures and Nanomedicine, Institute of High Pressure Physics, Polish Academy of Sciences, 29/37 Sokolowska Street, 01142 Warsaw, Poland.ORCID 0000-0003-2304-1481
Damian FudalaLaboratory of Nanostructures and Nanomedicine, Institute of High Pressure Physics, Polish Academy of Sciences, 29/37 Sokolowska Street, 01142 Warsaw, Poland.
Bartosz WoźniakLaboratory of Nanostructures and Nanomedicine, Institute of High Pressure Physics, Polish Academy of Sciences, 29/37 Sokolowska Street, 01142 Warsaw, Poland.
Justyna NasiłowskaDepartment of Microbiology, Prof. Wacław Dąbrowski Institute of Agriculture and Food Biotechnology-State Research Institute, 36 Rakowiecka Street, 02532 Warsaw, Poland.
Anna Swiderska-SrodaLaboratory of Nanostructures and Nanomedicine, Institute of High Pressure Physics, Polish Academy of Sciences, 29/37 Sokolowska Street, 01142 Warsaw, Poland.
Maciej LojkowskiFaculty of Materials Science and Engineering, Warsaw University of Technology, 141 Woloska Street, 02507 Warsaw, Poland.
Barbara SokołowskaDepartment of Microbiology, Prof. Wacław Dąbrowski Institute of Agriculture and Food Biotechnology-State Research Institute, 36 Rakowiecka Street, 02532 Warsaw, Poland.ORCID 0000-0002-6217-2401
Wojciech SwieszkowskiFaculty of Materials Science and Engineering, Warsaw University of Technology, 141 Woloska Street, 02507 Warsaw, Poland.
Witold LojkowskiLaboratory of Nanostructures and Nanomedicine, Institute of High Pressure Physics, Polish Academy of Sciences, 29/37 Sokolowska Street, 01142 Warsaw, Poland.ORCID 0000-0001-8521-0688

Funding

European Regional Development Fund within the Operational Programme "Innovative Economy" for 2007-2013. CePT project (reference no. POIG.02.02.00-14-024/08)National Center for Research and Development, Poland STRATEGMED3/306888/3/ NCBR/2017, project iTE
6 · The paper itself

Abstract

Medical implant use is associated with a risk of infection caused by bacteria on their surface. Implants with a surface that has both bone growth-promoting properties and antibacterial properties are of interest in orthopedics. In the current study, we fabricated a bioactive coating of hydroxyapatite nanoparticles on polyether ether ketone (PEEK) using the sonocoating method. The sonocoating method creates a layer by immersing the object in a suspension of nanoparticles in water and applying a high-power ultrasound. We show that the simple layer fabrication method results in a well-adhering layer with a thickness of 219 nm to 764 nm. Dropping cefuroxime sodium salt (Cef) antibiotic on the coated substrate creates a layer with a drug release effect and antibacterial activity against

Indexed as

antibacterial coatingcefuroxime sodium salt antibioticdrug releasehydroxyapatite nanoparticlesPEEK implantssonocoatingStaphylococcus aureus bacteria

Identifiers

PMID34203218
PMCPMC8307745

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.