ReviewPolymers2021
How to Sterilize Polylactic Acid Based Medical Devices?
Review in Polymers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
47 citing papers in PubMed, 86 citations in OpenAlex.
- Implantable Polymer-Based Medical Devices Go Supercritical: From Cleaning to Sterilization.Annals of biomedical engineering · 2026Review
- 3D-Printed and Biofabricated Scaffolds for Osteoporotic Bone Defect Repair: Mechanical Adaptation, Redox Control, Senescence Modulation and Osteoimmunomodulation.Bioengineering (Basel, Switzerland) · 2026Review
- 3D-Printed PLA/PETG Sterilizable Static/Dynamic Modular External Finger Fracture Fixator.Bioengineering (Basel, Switzerland) · 2026Article
- Polyethylene Terephthalate Glycol-Modified (PETG) as a Reusable and Biocompatible Substrate for Cell Culture Applications.Journal of functional biomaterials · 2026Article
- Ozone as a Next-Generation Sterilization Process in Tissue Engineering and Regenerative Medicine: Critically Bridging Product Stability, Safety and Clinical Translation.Molecules (Basel, Switzerland) · 2026Review
- Article
- Antibiotic-Loaded PLA Composites for Local Prevention of Implant-Associated Infections: Comparative Evaluation Against Reference Strains and Clinical Isolates.Antibiotics (Basel, Switzerland) · 2026Article
- Advancing Sterilization of Medical Implant Polymers: Novel Low-Temperature Deep-vacuum Vaporized HPharmaceutical research · 2026Article
- A comprehensive review on "bushy bunched" filamentous fungal mycelial hyphae for next-generation surgical sutures - a sustainable approach.Antonie van Leeuwenhoek · 2026Review
- Accuracy of Three-Dimensionally Printed, Patient-Specific Drill Guides for Implant Placement in Canine Cervical Vertebrae: A Cadaveric Study.Veterinary sciences · 2025Article
- Article
- Advances in 3D-Printed Drug Delivery and Screening Platforms for Bone Disease Therapy.Pharmaceutics · 2025Review
- Dimensional accuracy of 3D-printed surgical cutting guides after hospital sterilization: a comparative evaluation of ten MEX materials.3D printing in medicine · 2025Article
- Physico-mechanical characterization of 3D-printed PLGA for patient-specific resorbable implants in craniofacial surgery.Scientific reports · 2025Article
- Controlling Plasma-Functionalized Fillers for Enhanced Properties of PLA/ZnO Biocomposites: Effects of Excess l-Lactic Acid and Biomedical Implications.ACS applied materials & interfaces · 2025Article
- Evaluation of High-Temperature Sterilization Processes: Their Influence on the Mechanical Integrity of Additively Manufactured Polymeric Biomaterials.Materials (Basel, Switzerland) · 2025Article
- Delayed delivery of antibiotics by ultrasound-mediated rupture of polylactic acid pockets: In vitro and in vivo studies.PloS one · 2025Article
- The Influence of the Steam Sterilization Process on Selected Properties of Polymer Samples Produced in MEX and JMT Processes.Materials (Basel, Switzerland) · 2024Article
- In Vivo Study of Organ and Tissue Stability According to the Types of Bioresorbable Bone Screws.Materials (Basel, Switzerland) · 2024Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
Abstract
How sterilization techniques accurately affect the properties of biopolymers continues to be an issue of discussion in the field of biomedical engineering, particularly now with the development of 3D-printed devices. One of the most widely used biopolymers in the manufacture of biomedical devices is the polylactic acid (PLA). Despite the large number of studies found in the literature on PLA devices, relatively few papers focus on the effects of sterilization treatments on its properties. It is well documented in the literature that conventional sterilization techniques, such as heat, gamma irradiation and ethylene oxide, can induced damages, alterations or toxic products release, due to the thermal and hydrolytical sensitivity of PLA. The purposes of this paper are, therefore, to review the published data on the most common techniques used to sterilize PLA medical devices and to analyse how they are affecting their physicochemical and biocompatible properties. Emerging and alternative sterilization methods for sensitive biomaterials are also presented.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.