Evidence map›Paper›PMID 34203120›Full record

ArticleInternational journal of molecular sciences2021

Activated Alpha-2 Macroglobulin Improves Insulin Response via LRP1 in Lipid-Loaded HL-1 Cardiomyocytes.

Virginia Actis Dato, Gustavo Alberto Chiabrando

Open access · goldAbstract read
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
0.6field-weighted citation impact, top 36% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Intracellular Signaling Regulated by Activated αInternational journal of molecular sciences · 2026
    Review
  3. Review
  4. Article
  5. Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

Virginia Actis DatoCentro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba 5000, Argentina.
Gustavo Alberto ChiabrandoCentro de Investigaciones en Bioquímica Clínica e Inmunología (CIBICI), Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Córdoba 5000, Argentina.ORCID 0000-0001-8902-6693
Consejo Nacional de Investigaciones Científicas y Técnicas · AR

Funding

Agencia Nacional de Promoción Científica y Tecnológica Préstamo BID PICT 2015 0807 and Préstamo BID PICT 2017 4497Secretaría de Ciencia y Tecnología de la Universidad Nacional de Córdoba Consolidar 2018-2021
6 · The paper itself

Abstract

Activated alpha-2 Macroglobulin (α

Indexed as

AnimalsBlotting, WesternCell LineCell MembraneGlucoseInsulinLipoproteins, LDLLow Density Lipoprotein Receptor-Related Protein-1MacroglobulinsMiceMicroscopy, ConfocalMyocytes, CardiacReal-Time Polymerase Chain ReactionSignal TransductionGlucoseInsulinLipoproteins, LDLLow Density Lipoprotein Receptor-Related Protein-1Lrp1 protein, mouseMacroglobulinsglucoseheartlipoproteinLRP1metabolism

Identifiers

PMID34203120
PMCPMC8268138
OpenAlexW3176887449

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.