ArticleDiagnostics (Basel, Switzerland)2021
Cytohistological Correlation in Pleural Effusions Based on the International System for Reporting Serous Fluid Cytopathology.
Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed.
- Not Enough Cells: How Insufficient Cytological Specimens Are Mirrored by Reporting Systems - Journey from the Bethesda to the WHO Reporting Systems.Acta cytologica · 2026Review
- Ensemble based in transfer learning for cytological classification in pleural fluid.Frontiers in digital health · 2026Article
- Therapeutic and Formulation Innovations in the Management of Canine Otitis Externa.Pharmaceutics · 2025Review
- A comparative study of diagnostic accuracy in 3026 pleural biopsies and matched pleural effusion cytology with clinical correlation.Cancer medicine · 2023Article
- The International System for Reporting Serous Fluid Cytopathology-An Updated Review.Journal of clinical and translational pathology · 2023Article
- Cyto-Histopathological Correlations in Pathology Diagnostics.Diagnostics (Basel, Switzerland) · 2022Article
- A retrospective analysis of serous effusions based on the newly proposed international system for reporting serous fluid cytopathology: a report of 3633 cases in an oncological center.Diagnostic pathology · 2022Article
- Application of the International System for Reporting Serous Fluid Cytopathology with Cytohistological Correlation and Risk of Malignancy Assessment.Diagnostics (Basel, Switzerland) · 2021Article
- Role of Ancillary Techniques in Reporting Serous Fluid Cytology - "Redefining Categories, Refining Diagnosis".Journal of cytologyArticle
- The Role of Novel Tiered Reporting System in Serous Fluid Cytology and Risk of Malignancy Assessment: A Retrospective Study in a Tertiary Care Center.Journal of cytologyArticle
- The International System for Reporting Serous Fluid Cytopathology: The Need for Version 2.0.Journal of cytologyArticle
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Authors and funding
8 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The International System for Reporting Serous Fluid Cytology (TIS) was recently developed. Given its novelty, most studies looking into the risk of malignancy (ROM) of serous effusion diagnostic categories were published before the development of TIS. We searched the database of our department for pleural effusions diagnosed in the last five years, excluding those without a corresponding pleural biopsy. Cases were reviewed and reclassified according to the TIS. A cytohistological correlation was performed. In total, 350 pleural effusion specimens with one or more corresponding pleural biopsies were included. After reclassification, 5 (1.43%) were nondiagnostic (ND), 253 (72.29%) were negative for malignancy (NFM), 7 (2.00%) had atypia of unknown significance (AUS), 14 (4.00%) were suspicious for malignancy (SFM), and 71 (20.57%) were malignant (MAL). Calculated ROM was 40% for ND, 20.16% for NFM, 42.86% for AUS, 78.57% for SFM, and 100% for MAL. Effusion cytology sensitivity and specificity were 60.29% and 98.56%, respectively. This is the first publication looking into the cytohistological correlation of a retrospective cohort of pleural effusions based on the TIS. We add to the body of data regarding the ROM for TIS categories, highlighting areas of potential future research.
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