Evidence map›Paper›PMID 34203004›Full record

ReviewMolecules (Basel, Switzerland)2021

Immunomodulatory Effects of Green Tea Polyphenols.

Shuzhen Wang, Zhiliang Li, Yuting Ma, Yan Liu, Chi-Chen Lin, Shiming Li, Jianfeng Zhan, Chi-Tang Ho

Open access · goldAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.

0numbers the graph read from it
0cells of the map it votes in
49citing papers in PubMed
12.8field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

49 citing papers in PubMed, 120 citations in OpenAlex.

  1. Article
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  10. Multitargeted Effects ofInternational journal of molecular sciences · 2025
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  14. Quercetin and Silybin Decrease Intracellular Replication ofInternational journal of molecular sciences · 2025
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 3 institutions in 3 countries.

Shuzhen WangHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Hubei Zhongke Research Institute of Industrial Technology, College of Life Science, Huanggang Normal University, Huanggang 438000, China.
Zhiliang LiHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Hubei Zhongke Research Institute of Industrial Technology, College of Life Science, Huanggang Normal University, Huanggang 438000, China.
Yuting MaHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Hubei Zhongke Research Institute of Industrial Technology, College of Life Science, Huanggang Normal University, Huanggang 438000, China.
Yan LiuHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Hubei Zhongke Research Institute of Industrial Technology, College of Life Science, Huanggang Normal University, Huanggang 438000, China.
Chi-Chen LinInstitute of Biomedical Science, The iEGG and Animal Biotechnology Center, National Chung-Hsing University, Taichung 402, Taiwan.ORCID 0000-0002-1464-0231
Shiming LiHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Hubei Zhongke Research Institute of Industrial Technology, College of Life Science, Huanggang Normal University, Huanggang 438000, China.
Jianfeng ZhanHubei Collaborative Innovation Center for the Characteristic Resources Exploitation of Dabie Mountains, Hubei Zhongke Research Institute of Industrial Technology, College of Life Science, Huanggang Normal University, Huanggang 438000, China.
Chi-Tang HoDepartment of Food Science, Rutgers University, New Brunswick, NJ 08901, USA.ORCID 0000-0001-8273-2085
Huanggang Normal University · CNNational Chung Hsing University · TWRutgers, The State University of New Jersey · US

Funding

Hubei Provincial Key Laboratory of Economic Forest Germplasm Improvement and Comprehensive Utilization of Resources 201932103
6 · The paper itself

Abstract

Green tea and its bioactive components, especially polyphenols, possess many health-promoting and disease-preventing benefits, especially anti-inflammatory, antioxidant, anticancer, and metabolic modulation effects with multi-target modes of action. However, the effect of tea polyphenols on immune function has not been well studied. Moreover, the underlying cellular and molecular mechanisms mediating immunoregulation are not well understood. This review summarizes the recent studies on the immune-potentiating effects and corresponding mechanisms of tea polyphenols, especially the main components of (-)-epigallocatechin-3-gallate (EGCG) and (-)-epicatechin-3-gallate (ECG). In addition, the benefits towards immune-related diseases, such as autoimmune diseases, cutaneous-related immune diseases, and obesity-related immune diseases, have been discussed.

Indexed as

AnimalsAntioxidantsBiological ProductsCatechinFlavonoidsHumansImmunityImmunologic FactorsPolyphenolsTeaAntioxidantsBiological ProductsCatechinepicatechin gallateepigallocatechin gallateFlavonoidsImmunologic FactorsPolyphenolsTeaanti-inflammatory actionautoimmune diseasesepigallocatechin-3-gallate (EGCG)green tea polyphenolsimmunomodulatory

Identifiers

PMID34203004
PMCPMC8234133
OpenAlexW3175316394

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.