ArticleMetabolites2021
A Metabolic Choreography of Maize Plants Treated with a Humic Substance-Based Biostimulant under Normal and Starved Conditions.
Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed.
- Light-defined cold acclimation reprograms organ-specific metabolic and transcriptional landscapes for salt stress responses in maize.Plant cell reports · 2026Article
- Temporal and stimulus-specific transcriptional responses of maize to a biostimulant mixture of quillaja extract and fulvic acid.PloS one · 2026Article
- The optimization of crop response to climatic stress through modulation of plant stress response mechanisms. Opportunities for biostimulants and plant hormones to meet climate challenges.The New phytologist · 2026Review
- Mangrove derived coactive bacterial inoculant triggered biochemical traits rejuvenating plant cell function under salt stress.Plant cell reports · 2025Article
- Seed Metabolomic Landscape Reflecting Key Differential Metabolic Profiles Among Different Wheat Cultivars.Metabolites · 2025Article
- Metabolomic Reconfiguration in Primed Barley (Metabolites · 2023Article
- Comparative metabolomic profiling ofFrontiers in plant science · 2023Article
- Humic acids enhance salt stress tolerance associated with pyrroline 5-carboxylate synthetase gene expression and hormonal alteration in perennial ryegrass (Frontiers in plant science · 2023Article
- Computational Metabolomics to Elucidate Molecular Signaling and Regulatory Mechanisms Associated with Biostimulant-Mediated Growth Promotion and Abiotic Stress Tolerance in Crop Plants.Methods in molecular biology (Clifton, N.J.) · 2023Article
- Changes in Metabolic Profile of Rice Leaves Induced by Humic Acids.Plants (Basel, Switzerland) · 2022Article
- Review
- Humic Substances as Microalgal Biostimulants-Implications for Microalgal Biotechnology.Marine drugs · 2022Review
- Metabolic Circuits in Sap Extracts Reflect the Effects of a Microbial Biostimulant on Maize Metabolism under Drought Conditions.Plants (Basel, Switzerland) · 2022Article
- Untargeted metabolite profiling to elucidate rhizosphere and leaf metabolome changes of wheat cultivars (Frontiers in microbiology · 2022Article
- Article
Corrections and comments
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Authors and funding
9 authors.
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Abstract
Humic substance (HS)-based biostimulants show potentials as sustainable strategies for improved crop development and stress resilience. However, cellular and molecular mechanisms governing the agronomically observed effects of HS on plants remain enigmatic. Here, we report a global metabolic reprogramming of maize leaves induced by a humic biostimulant under normal and nutrient starvation conditions. This reconfiguration of the maize metabolism spanned chemical constellations, as revealed by molecular networking approaches. Plant growth and development under normal conditions were characterized by key differential metabolic changes such as increased levels of amino acids, oxylipins and the tricarboxylic acid (TCA) intermediate, isocitric acid. Furthermore, under starvation, the humic biostimulant significantly impacted pathways that are involved in stress-alleviating mechanisms such as redox homeostasis, strengthening of the plant cell wall, osmoregulation, energy production and membrane remodelling. Thus, this study reveals that the humic biostimulant induces a remodelling of inter-compartmental metabolic networks in maize, subsequently readjusting the plant physiology towards growth promotion and stress alleviation. Such insights contribute to ongoing efforts in elucidating modes of action of biostimulants, generating fundamental scientific knowledge that is necessary for development of the biostimulant industry, for sustainable food security.
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