Evidence map›Paper›PMID 34202935›Full record

Trial reportGenes2021

Framing Effects on Decision-Making for Diagnostic Genetic Testing: Results from a Randomized Trial.

Andrew A Dwyer, Hongjie Shen, Ziwei Zeng, Matt Gregas, Min Zhao

Registry-linked trialOpen access · goldAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Genes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT04372888 (Examining Choice Architecture for Genetic Testing Decisions), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
0.5field-weighted citation impact, top 41% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT04372888 nacompletednot on this map

Examining Choice Architecture for Genetic Testing Decisions

TypeinterventionalSponsorBoston CollegeRan2020 to 2020Enrolled1,012ConditionsDecision MakingArmschoice decision frame, opt-in decision frame, opt-out decision frame, enhanced choice (context) decision frame, enhanced choice (norms) decision frame
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 8 citations in OpenAlex.

  1. Pooled it
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 1 institution in 1 country.

Andrew A DwyerWilliam F. Connell School of Nursing, Boston College, Chestnut Hill, MA 02467, USA.ORCID 0000-0002-7023-6794
Hongjie ShenDepartment of Measurement, Evaluation, Statistics and Assessment, Lynch School of Education, Boston College, Chestnut Hill, MA 02467, USA.
Ziwei ZengDepartment of Measurement, Evaluation, Statistics and Assessment, Lynch School of Education, Boston College, Chestnut Hill, MA 02467, USA.
Matt GregasDepartment of Research Services, Boston College, Chestnut Hill, MA 02467, USA.
Min ZhaoCarroll School of Management, Boston College, Chestnut Hill, MA 02467, USA.
Boston College · US

Funding

The Massachusetts General Hospital Harvard Center for Reproductive MedicineP50HD104224 · NICHD · MASSACHUSETTS GENERAL HOSPITAL · PI TALKOWSKI, MICHAEL E · 2021 to 2025
$7.8M
Eunice Kennedy Shriver National Institute of Child Health and Human Development 1P50HD104224-01
6 · The paper itself

Abstract

Genetic testing is increasingly part of routine clinical care. However, testing decisions may be characterized by regret as findings also implicate blood relatives. It is not known if genetic testing decisions are affected by the way information is presented (i.e., framing effects). We employed a randomized factorial design to examine framing effects on hypothetical genetic testing scenarios (common, life-threatening disease and rare, life-altering disease). Participants (

Indexed as

Choice BehaviorGenetic TestingPatient PreferenceAdultFemaleGenetic CounselingHereditary Breast and Ovarian Cancer SyndromeHumansHypogonadismMaleMiddle AgedPatient Education as Topicchoice architecturecongenital hypogonadotropic hypogonadismdecision-makinggenetic counsellinggenetic testinghereditary breast and ovarian cancertheory of planned behavior

Identifiers

PMID34202935
PMCPMC8234313
OpenAlexW3174818582

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.