ArticleChildren (Basel, Switzerland)2021
Cross-Union Surgery for Congenital Pseudarthrosis of the Tibia.
Article in Children (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 35 citations in OpenAlex.
- Angular Improvement with Bracing Over 7 Years in Anterolateral Tibial Bowing without Neurofibromatosis Type 1: A Case Report.Journal of orthopaedic case reports · 2026Article
- Neurofibromin in bone disease: Mechanisms and therapeutic implications (Review).International journal of molecular medicine · 2026Review
- Extent of the low-density line is associated with time to fracture in children with congenital anterolateral bowing of the tibia: a retrospective survival analysis.Frontiers in pediatrics · 2026Article
- An Autologous Human Adipose Stem Cell-Derived 3D Osteogenic Implant for Bone Grafting: From Development to First-in-Human Experience.Journal of clinical medicine · 2025Article
- Molecular Basis of Fracture Pseudarthrosis Associated with Neurofibromatosis Type 1.Journal of the Pediatric Orthopaedic Society of North America · 2025Review
- Combined surgery with intramedullary rod fixation across the ankle for the treatment of Crawford IV congenital pseudarthrosis of the tibia: a long-term follow-up study.Orphanet journal of rare diseases · 2025Article
- Unraveling the molecular landscape of congenital pseudoarthrosis of the tibia: insights from a comprehensive analysis of 159 probands.Orphanet journal of rare diseases · 2025Article
- Efficacy of the cross-union protocol in the treatment of congenital tibial pseudarthrosis: a comparative study.BMC musculoskeletal disorders · 2025Article
- Cross-union surgery for tibiofibular fractures in McCune-Albright syndrome: a case report and literature review.Frontiers in pediatrics · 2025Article
- [Clinical study of Cross-Union surgery for treatment of pseudarthrosis of tibia with neurofibromatosis type 1 in children].Zhongguo xiu fu chong jian wai ke za zhi = Zhongguo xiufu chongjian waike zazhi = Chinese journal of reparative and reconstructive surgery · 2024Article
- Ilizarov Distraction for Congenital Pseudoarthrosis of the Tibia in Adults.Orthopaedic surgery · 2024Article
- What's new in pediatric lower limb reconstruction?Journal of children's orthopaedics · 2024Article
- Congenital tibial pseudarthrosis: A challenge in pediatric radiology.Radiology case reports · 2024Article
- Comparative study of different extendable intramedullary rods combined with surgery in the treatment of congenital pseudarthrosis of the tibia.Orphanet journal of rare diseases · 2024Article
- Anterolateral Tibial Bowing and Congenital Pseudoarthrosis of the Tibia: Current Concept Review and Future Directions.Current reviews in musculoskeletal medicine · 2022Review
- Functional and radiological outcomes after treatment of congenital pseudarthrosis of the tibia using the Ilizarov technique: a retrospective single-center study.Journal of orthopaedics and traumatology : official journal of the Italian Society of Orthopaedics and Traumatology · 2022Article
- Analysis of related factors of behavioral problems in children with congenital pseudarthrosis of tibia.Revista da Associacao Medica Brasileira (1992) · 2022Article
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3 authors.
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Abstract
Congenital Pseudoarthrosis of the Tibia (CPT) is a rare condition with a reputation for recurrent fractures and failure to achieve union. A large variety of surgical procedures have been attempted for the treatment of fractured cases of CPT with an average rate of union without refracture of only 50%. Intentional cross-union between the tibia and fibula has been reported to improve these results to 100% union with no refractures. This is a retrospective study of 39 cases of CPT in 36 patients treated by the Paley cross-union protocol with internal fixation, bone grafting, zoledronic acid infusion and bone morphogenic protein 2 (BMP2) insertion. All 39 cases of CPT united at the tibia and developed a cross-union to the fibula. Two patients had a persistent fibular pseudarthrosis, one that was later treated at the time of planned rod exchange and one that has remained asymptomatic. There were few postoperative complications. There were no refractures during the up to 7-year follow-up period. The most common problem was the Fassier-Duval (FD) rod pulling through the proximal or distal physis into the metaphysis (66.7%). This did not negatively affect the results and was remedied at the time of the planned rod exchange. The Paley Cross-Union Protocol is very technically demanding, but the results have radically changed the prognosis of this once sinister disease.
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