Evidence map›Paper›PMID 34202906›Full record

ArticleCancers2021

Oxidative Stress Biomarkers in Urine of Metal Carpentry Workers Can Be Diagnostic for Occupational Exposure to Low Level of Welding Fumes from Associated Metals.

Flavia Buonaurio, Maria Luisa Astolfi, Daniela Pigini, Giovanna Tranfo, Silvia Canepari, Antonio Pietroiusti, Iacopo D'Alessandro, Renata Sisto

Abstract read
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed.

  1. Review
  2. Article
  3. MUC1 in the upper-lower airway inflammatory continuum: an endotype-centered perspective.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2025
    Review
  4. Association between size-resolved PMScientific reports · 2025
    Article
  5. Article
  6. Review
  7. Article
  8. Review
  9. Article
  10. The MAK collection for occupational health and safety · 2024
    Review
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors.

Flavia BuonaurioDepartment of Chemistry, Sapienza University, 00185 Rome, Italy.
Maria Luisa AstolfiDepartment of Chemistry, Sapienza University, 00185 Rome, Italy.ORCID 0000-0001-9633-8484
Daniela PiginiDepartment of Occupational Medicine, Epidemiology and Hygiene, INAIL Research Center, Monte Porzio Catone, 00078 Rome, Italy.
Giovanna TranfoDepartment of Occupational Medicine, Epidemiology and Hygiene, INAIL Research Center, Monte Porzio Catone, 00078 Rome, Italy.ORCID 0000-0001-8973-6046
Silvia CanepariDepartment of Environmental Biology, Sapienza University, 00185 Rome, Italy.ORCID 0000-0002-4360-0140
Antonio PietroiustiDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.
Iacopo D'AlessandroDepartment of Biomedicine and Prevention, University of Tor Vergata, 00133 Rome, Italy.
Renata SistoDepartment of Occupational Medicine, Epidemiology and Hygiene, INAIL Research Center, Monte Porzio Catone, 00078 Rome, Italy.

Funding

Istituto Nazionale per l'Assicurazione Contro Gli Infortuni sul Lavoro BRIC ID09/ PAR 2019 - 2021
6 · The paper itself

Abstract

Urinary concentrations of 16 different exposure biomarkers to metals were determined at the beginning and at the end of a working shift on a group of workers in the metal carpentry industry. Five different oxidative stress biomarkers were also measured, such as the oxidation products of RNA and DNA metabolized and excreted in the urine. The results of workers exposed to metals were compared to those of a control group. The metal concentrations found in these workers were well below the occupational exposure limit values and exceeded the mean concentrations of the same metals in the urine of the control group by a factor of four at maximum. Barium (Ba), mercury (Hg), lead (Pb) and strontium (Sr) were correlated with the RNA oxidative stress biomarker, 8-oxo-7, 8-dihydroguanosine (8-oxoGuo), which was found able to discriminate exposed workers from controls with a high level of specificity and sensitivity. The power of this early diagnostic technique was assessed by means of the ROC curve. Ba, rubidium (Rb), Sr, tellurium (Te), and vanadium (V) were correlated with the level of the protein oxidation biomarker 3-Nitrotyrosine (3-NO

Indexed as

effect biomarkershuman biomonitoringmixturesoccupational exposureoxidative stresstoxic metals

Identifiers

PMID34202906
PMCPMC8268877

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.