Evidence map›Paper›PMID 34202844›Full record

ReviewMolecules (Basel, Switzerland)2021

A Brief Overview of Potential Treatments for Viral Diseases Using Natural Plant Compounds: The Case of SARS-Cov.

Rambod Abiri, Hazandy Abdul-Hamid, Oksana Sytar, Ramin Abiri, Eduardo Bezerra de Almeida, Surender K Sharma, Victor P Bulgakov, Randolph R J Arroo, Sonia Malik

Open access · goldAbstract readReview
In one paragraph

Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
10.3field-weighted citation impact, top 2% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 41 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Marine AlgaMarine drugs · 2022
    Article
  9. Discovery of Natural Lead Compound fromPharmaceuticals (Basel, Switzerland) · 2022
    Article
  10. Article
  11. Article
  12. Article
  13. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 7 institutions in 9 countries.

Rambod AbiriDepartment of Forestry Science and Biodiversity, Faculty of Forestry and Environment, Universiti Putra Malaysia, Serdang 43400, Malaysia.ORCID 0000-0002-7538-1392
Hazandy Abdul-HamidDepartment of Forestry Science and Biodiversity, Faculty of Forestry and Environment, Universiti Putra Malaysia, Serdang 43400, Malaysia.ORCID 0000-0002-3525-556X
Oksana SytarEducational and Scientific Center "Institute of Biology and Medicine", Department of Plant Biology, Taras Shevchenko National University of Kyiv, Volodymyrska 60, 01033 Kyiv, Ukraine.ORCID 0000-0003-4219-9292
Ramin AbiriDepartment of Microbiology, School of Medicine, Kermanshah University of Medical Sciences, Kermanshah 6718773654, Iran.
Eduardo Bezerra de AlmeidaBiological and Health Sciences Centre, Laboratory of Botanical Studies, Department of Biology, Federal University of Maranhão, São Luís 65080-805, MA, Brazil.
Surender K SharmaDepartment of Physics, Central University of Punjab, Bathinda 151401, India.ORCID 0000-0002-6924-7699
Victor P BulgakovDepartment of Biotechnology, Federal Scientific Center of the East Asia Terrestrial Biodiversity (Institute of Biology and Soil Science), Far Eastern Branch of the Russian Academy of Sciences, 159 Stoletija Str., 690022 Vladivostok, Russia.ORCID 0000-0003-2264-9161
Randolph R J ArrooLeicester School of Pharmacy, De Montfort University, The Gateway, Leicester LE1 9BH, UK.ORCID 0000-0002-0672-7927
Sonia MalikHealth Sciences Graduate Program, Biological & Health Sciences Centre, Federal University of Maranhão, São Luís 65080-805, MA, Brazil.ORCID 0000-0001-5224-3838
Universiti Putra Malaysia · MYCentral University of Punjab · INDe Montfort University · GBFederal Scientific Center of the East Asia Terrestrial Biodiversity FEB RAS · RUSlovak University of Agriculture in Nitra · SKUniversidade Federal do Maranhão · BRUniversité d'Orléans · FR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The COVID-19 pandemic, as well as the more general global increase in viral diseases, has led researchers to look to the plant kingdom as a potential source for antiviral compounds. Since ancient times, herbal medicines have been extensively applied in the treatment and prevention of various infectious diseases in different traditional systems. The purpose of this review is to highlight the potential antiviral activity of plant compounds as effective and reliable agents against viral infections, especially by viruses from the coronavirus group. Various antiviral mechanisms shown by crude plant extracts and plant-derived bioactive compounds are discussed. The understanding of the action mechanisms of complex plant extract and isolated plant-derived compounds will help pave the way towards the combat of this life-threatening disease. Further, molecular docking studies, in silico analyses of extracted compounds, and future prospects are included. The in vitro production of antiviral chemical compounds from plants using molecular pharming is also considered. Notably, hairy root cultures represent a promising and sustainable way to obtain a range of biologically active compounds that may be applied in the development of novel antiviral agents.

Indexed as

COVID-19 Drug TreatmentAntiviral AgentsComputer SimulationHumansMolecular FarmingPlant ExtractsPlants, MedicinalSARS-CoV-2Virus ReplicationAntiviral AgentsPlant Extractsbioactive compoundscoronavirushairy rootsherbal medicinesmolecular farmingplant extractsrespiratory diseases

Identifiers

PMID34202844
PMCPMC8270261
OpenAlexW3173271539

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.