Evidence map›Paper›PMID 34202817›Full record

ArticleJournal of clinical medicine2021

Neurosurgical Considerations Regarding Decompressive Craniectomy for Intracerebral Hemorrhage after SARS-CoV-2-Vaccination in Vaccine Induced Thrombotic Thrombocytopenia-VITT.

Florian Gessler, Ann Kristin Schmitz, Daniel Dubinski, Joshua D Bernstock, Felix Lehmann, Sae-Yeon Won, Matthias Wittstock, Erdem Güresir, Alexis Hadjiathanasiou, Julian Zimmermann and 4 more

Open access · goldAbstract read
In one paragraph

Article in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
19citing papers in PubMed, 1 pooled it
6.1field-weighted citation impact, top 3% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

19 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.

  1. Pooled it
  2. Article
  3. Article
  4. Review
  5. COVID-19 vaccine-induced immune thrombotic thrombocytopenia: a review.Clinical and experimental vaccine research · 2023
    Review
  6. Rule out all differential causes before attributing cerebral bleeding to 5-aminolevulinic acid.Child's nervous system : ChNS : official journal of the International Society for Pediatric Neurosurgery · 2023
    Article
  7. Review
  8. Article
  9. Article
  10. Special Issue "COVID-19 and Venous Thromboembolism".Journal of clinical medicine · 2022
    Article
  11. Article
  12. Review
  13. Article
  14. Review
  15. Review
  16. Article
  17. Article
  18. Review
  19. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

14 authors at 4 institutions in 2 countries.

Florian GesslerDepartment of Neurosurgery, University Medicine Rostock, 18055 Rostock, Germany.ORCID 0000-0002-3471-0575
Ann Kristin SchmitzDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
Daniel DubinskiDepartment of Neurosurgery, University Medicine Rostock, 18055 Rostock, Germany.
Joshua D BernstockDepartment of Neurosurgery, Brigham and Women's Hospital, Harvard Medical School, Boston, MA 02115, USA.
Felix LehmannDepartment of Anesthesiology and Intensive Care Medicine, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0003-2847-9271
Sae-Yeon WonDepartment of Neurosurgery, University Medicine Rostock, 18055 Rostock, Germany.
Matthias WittstockDepartment of Neurology, University Medicine Rostock, 18055 Rostock, Germany.
Erdem GüresirDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0001-8319-0847
Alexis HadjiathanasiouDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-5477-8518
Julian ZimmermannDepartment of Neurology, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0003-1964-0078
Wolfgang MiesbachDepartment of Coagulation Disorders, University Hospital Frankfurt, 60590 Frankfurt, Germany.
Thomas FreimanDepartment of Neurosurgery, University Medicine Rostock, 18055 Rostock, Germany.
Hartmut VatterDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.
Patrick SchussDepartment of Neurosurgery, University Hospital Bonn, 53127 Bonn, Germany.ORCID 0000-0002-5806-2576
University Hospital Bonn · DEUniversity of Rostock · DEBrigham and Women's Hospital · USGoethe University Frankfurt · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Given the ongoing global SARS-CoV-2-vaccination efforts, clinical awareness needs to be raised regarding the possibility of an increased incidence of SARS-CoV-2-vaccine-related immune-mediated thrombocytopenia in patients with intracerebral hemorrhage (ICH) secondary to cerebral sinus and vein thrombosis (CVT) requiring (emergency) neurosurgical treatment in the context of vaccine-induced immune thrombotic thrombocytopenia (VITT). Only recently, an association of vaccinations and cerebral sinus and vein thrombosis has been described. In a number of cases, neurosurgical treatment is warranted for these patients and special considerations are warranted when addressing the perioperative coagulation. We, herein, describe the past management of patients with VITT and established a literature-guided algorithm for the treatment of patients when addressing the impaired coagulation in these patients. Increasing insights addressing the pathophysiology of SARS-CoV-2-vaccine-related immune-mediated thrombocytopenia guide physicians in developing an interdisciplinary algorithm taking into account the special considerations of this disease.

Indexed as

cerebral sinus and vein thrombosis (CVT)Covid-19decompressive craniectomyintracerebral hemorrhage (ICH)SARS-CoV-2vaccinationvaccine-induced immune thrombotic thrombocytopenia (VITT)

Identifiers

PMID34202817
PMCPMC8269113
OpenAlexW3176305977

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.